Setting description

Taxel_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 3 264 0 1
TP53- & AR- 1 375 2 1
TP53+ 1 278 1 0
DRD+ 1 100 0 0
TEfus+ 0 260 1 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.006 0.528 0.000 0.002
TP53- & AR- 0.002 0.750 0.004 0.002
TP53+ 0.002 0.556 0.002 0.000
DRD+ 0.002 0.200 0.000 0.000
TEfus+ 0.000 0.520 0.002 0.002
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 100 0 74 79
TP53- & AR- 409 0 390 403
TP53+ 229 0 223 231
DRD+ 111 0 183 175
TEfus+ 198 0 191 209
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.200 0 0.148 0.158
TP53- & AR- 0.818 0 0.780 0.806
TP53+ 0.458 0 0.446 0.462
DRD+ 0.222 0 0.366 0.350
TEfus+ 0.396 0 0.382 0.418
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 5 14 30 17
TP53+ 19 77 24 22
DRD+ 0 0 0 0
TEfus+ 1 1 2 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.010 0.028 0.060 0.034
TP53+ 0.038 0.154 0.048 0.044
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.002 0.002 0.004 0.004


Errors & power

The overall error was 0.456.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.440             0.008             0.006 

The overall power was 0.528.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.528             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 0 0 3 1 264
futility 74 0 100 79 0
max_n 0 0 0 0 0
n 155 (94, 249) 432 (352, 477) 139 (80, 225) 154 (89, 244) 142 (49, 278)
n_unique 144 (87, 239) 401 (329, 445) 130 (74, 211) 144 (82, 231) 132 (45, 259)
time_trial 36 (33, 36) 36 (36, 36) 36 (25, 36) 36 (31, 36) 32 (8, 36)
time_stop 30 (20, 36) NA (NA, NA) 25 (4, 35) 29 (20, 35) 14 (6, 28)
post_p 0 (0, 0.01) NA (NA, NA) 0 (0, 0.01) 0 (0, 0.01) 1 (1, 1)
rate 0.113 (0.101, 0.129) 0.075 (0.069, 0.081) 0.114 (0.101, 0.131) 0.113 (0.102, 0.13) 0.036 (0.031, 0.041)
DRD+ graduation 0 0 1 0 100
futility 183 0 111 175 0
max_n 0 0 0 0 0
n 55 (33, 80) 112 (90, 133) 41 (19, 69) 53 (29, 83) 26 (5, 59)
n_unique 51 (30, 76) 105 (83, 123) 38 (17, 63) 49 (27, 78) 24 (5, 56)
time_trial 36 (22, 36) 36 (36, 36) 36 (29, 36) 36 (20, 36) 36 (24, 36)
time_stop 26 (17, 34) NA (NA, NA) 30 (23, 35) 24 (16, 34) 24 (16, 33)
post_p 0.02 (0, 0.15) NA (NA, NA) 0.04 (0, 0.26) 0.02 (0, 0.16) 1 (0.87, 1)
rate 0.116 (0.096, 0.141) 0.075 (0.064, 0.086) 0.114 (0.093, 0.156) 0.114 (0.096, 0.145) 0.036 (0.023, 0.051)
TEfus+ graduation 1 0 0 1 260
futility 191 0 198 209 0
max_n 2 0 1 2 1
n 62 (33, 101) 155 (127, 178) 54 (25, 91) 59 (30, 105) 43 (20, 103)
n_unique 57 (31, 95) 144 (118, 167) 50 (23, 85) 54 (27, 96) 39 (18, 97)
time_trial 36 (20, 36) 36 (36, 36) 36 (21, 36) 36 (18, 36) 33 (11, 36)
time_stop 25 (17, 34) NA (NA, NA) 26 (17, 34) 23 (15, 35) 15 (10, 29)
post_p 0.02 (0, 0.15) NA (NA, NA) 0.02 (0, 0.16) 0.01 (0, 0.13) 1 (0.99, 1)
rate 0.113 (0.096, 0.138) 0.075 (0.066, 0.085) 0.115 (0.096, 0.144) 0.115 (0.097, 0.145) 0.037 (0.028, 0.045)
TP53- & AR- graduation 2 0 1 1 375
futility 390 0 409 403 0
max_n 30 0 5 17 14
n 47 (26, 136) 166 (99, 203) 39 (25, 105) 42 (25, 123) 31 (18, 116)
n_unique 43 (24, 130) 155 (92, 191) 37 (23, 101) 40 (24, 118) 29 (15, 111)
time_trial 23 (15, 36) 36 (36, 36) 19 (9, 36) 22 (13, 36) 15 (9, 36)
time_stop 21 (14, 31) NA (NA, NA) 17 (9, 30) 20 (13, 31) 12 (9, 24)
post_p 0.02 (0, 0.13) NA (NA, NA) 0.02 (0, 0.13) 0.02 (0, 0.14) 1 (0.98, 1)
rate 0.114 (0.098, 0.145) 0.075 (0.066, 0.085) 0.117 (0.098, 0.151) 0.115 (0.098, 0.142) 0.036 (0.027, 0.046)
TP53+ graduation 1 0 1 0 278
futility 223 0 229 231 0
max_n 24 0 19 22 77
n 71 (35, 127) 200 (173, 226) 66 (27, 120) 70 (32, 132) 59 (25, 152)
n_unique 66 (32, 118) 188 (162, 210) 61 (26, 114) 65 (30, 123) 56 (22, 143)
time_trial 36 (18, 36) 36 (36, 36) 36 (17, 36) 36 (17, 36) 30 (9, 36)
time_stop 24 (13, 34) NA (NA, NA) 24 (13, 34) 24 (15, 33) 14 (8, 29)
post_p 0.01 (0, 0.09) NA (NA, NA) 0.01 (0, 0.11) 0.01 (0, 0.09) 1 (0.99, 1)
rate 0.114 (0.098, 0.137) 0.075 (0.067, 0.084) 0.114 (0.096, 0.142) 0.114 (0.099, 0.142) 0.036 (0.029, 0.044)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 396 0 442 412 464
futility 0 0 0 0 0
max_n 30 0 5 17 14
n 24 (9, 86) 108 (63, 135) 23 (15, 67) 21 (8, 83) 22 (10, 83)
n_unique 22 (8, 83) 101 (57, 127) 22 (14, 66) 20 (7, 79) 21 (10, 80)
post_p 0.08 (0, 0.3) NA (NA, NA) 0.06 (0, 0.26) 0.07 (0, 0.33) 1 (0.92, 1)
rate 0.115 (0.093, 0.173) 0.075 (0.064, 0.087) 0.117 (0.093, 0.157) 0.115 (0.091, 0.173) 0.035 (0.026, 0.049)
—+ graduation 410 0 457 429 469
futility 0 0 0 0 0
max_n 31 0 5 19 14
n 6 (2, 16) 18 (10, 27) 6 (2, 15) 5 (2, 17) 5 (2, 12)
n_unique 5 (2, 16) 17 (9, 25) 5 (2, 14) 5 (1, 16) 5 (2, 11)
post_p 0.28 (0.11, 0.62) NA (NA, NA) 0.26 (0.09, 0.54) 0.28 (0.1, 0.58) 0.87 (0.53, 0.99)
rate 0.126 (0.073, 0.283) 0.074 (0.05, 0.111) 0.134 (0.082, 0.304) 0.13 (0.076, 0.392) 0.037 (0.017, 0.079)
–+- graduation 227 0 260 234 360
futility 0 0 0 0 0
max_n 24 0 19 22 73
n 16 (5, 51) 69 (57, 83) 16 (7, 51) 15 (5, 52) 22 (6, 63)
n_unique 15 (5, 49) 66 (54, 78) 15 (6, 49) 14 (5, 49) 21 (5, 61)
post_p 0.12 (0.03, 0.44) NA (NA, NA) 0.12 (0.02, 0.36) 0.13 (0.02, 0.41) 1 (0.83, 1)
rate 0.121 (0.088, 0.211) 0.076 (0.062, 0.092) 0.12 (0.091, 0.196) 0.12 (0.089, 0.23) 0.036 (0.023, 0.054)
–++ graduation 292 0 331 297 415
futility 0 0 0 0 0
max_n 25 0 19 23 71
n 11 (4, 33) 46 (33, 56) 12 (4, 33) 10 (4, 34) 14 (6, 40)
n_unique 10 (3, 32) 43 (31, 54) 11 (3, 31) 9 (3, 32) 13 (5, 37)
post_p 0.2 (0.04, 0.51) NA (NA, NA) 0.19 (0.05, 0.47) 0.18 (0.04, 0.46) 0.98 (0.76, 1)
rate 0.121 (0.082, 0.22) 0.076 (0.06, 0.096) 0.119 (0.084, 0.239) 0.125 (0.086, 0.241) 0.038 (0.023, 0.058)
-+– graduation 414 0 449 425 467
futility 0 0 0 0 0
max_n 30 0 5 17 14
n 8 (3, 20) 19 (10, 27) 4 (0, 14) 8 (3, 19) 3 (0, 11)
n_unique 7 (3, 19) 17 (8, 26) 4 (0, 14) 7 (2, 18) 2 (0, 10)
post_p 0.27 (0.09, 0.54) NA (NA, NA) 0.3 (0.12, 0.57) 0.26 (0.09, 0.54) 0.8 (0.48, 0.97)
rate 0.124 (0.079, 0.265) 0.074 (0.051, 0.107) 0.137 (0.077, 0.494) 0.121 (0.08, 0.244) 0.039 (0.008, 0.091)
-+-+ graduation 423 0 465 438 472
futility 0 0 0 0 0
max_n 31 0 4 19 14
n 8 (3, 20) 17 (9, 27) 4 (0, 13) 6 (2, 19) 3 (0, 9)
n_unique 8 (3, 19) 16 (8, 25) 4 (0, 13) 6 (2, 17) 2 (0, 8)
post_p 0.29 (0.1, 0.61) NA (NA, NA) 0.31 (0.14, 0.59) 0.27 (0.09, 0.59) 0.82 (0.48, 0.98)
rate 0.12 (0.078, 0.29) 0.078 (0.051, 0.113) 0.136 (0.079, 0.411) 0.128 (0.082, 0.347) 0.039 (0, 0.101)
-++- graduation 281 0 286 280 381
futility 0 0 0 0 0
max_n 22 0 19 22 71
n 5 (2, 12) 13 (8, 18) 4 (1, 11) 5 (2, 12) 2 (0, 9)
n_unique 5 (2, 12) 12 (7, 17) 4 (1, 10) 5 (1, 11) 2 (0, 9)
post_p 0.31 (0.14, 0.62) NA (NA, NA) 0.34 (0.16, 0.61) 0.32 (0.15, 0.6) 0.77 (0.4, 0.95)
rate 0.127 (0.073, 0.316) 0.075 (0.048, 0.118) 0.127 (0.072, 0.395) 0.125 (0.07, 0.336) 0.041 (0, 0.14)
-+++ graduation 327 0 342 326 423
futility 0 0 0 0 0
max_n 23 0 19 23 69
n 5 (2, 13) 12 (7, 17) 4 (0, 10) 5 (1, 13) 2 (0, 7)
n_unique 5 (1, 12) 11 (6, 16) 3 (0, 10) 5 (1, 12) 2 (0, 7)
post_p 0.32 (0.14, 0.59) NA (NA, NA) 0.35 (0.16, 0.65) 0.32 (0.15, 0.66) 0.77 (0.41, 0.95)
rate 0.134 (0.079, 0.39) 0.078 (0.046, 0.125) 0.132 (0.072, 0.494) 0.134 (0.073, 0.348) 0.041 (0, 0.119)
+— graduation 74 0 103 80 264
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 15) 22 (15, 28) 5 (2, 16) 6 (2, 15) 13 (3, 26)
n_unique 5 (2, 15) 20 (14, 27) 5 (2, 14) 5 (2, 14) 12 (3, 24)
post_p 0.28 (0.1, 0.58) NA (NA, NA) 0.26 (0.11, 0.57) 0.28 (0.11, 0.54) 0.94 (0.64, 1)
rate 0.128 (0.073, 0.373) 0.076 (0.053, 0.106) 0.129 (0.075, 0.363) 0.128 (0.073, 0.313) 0.035 (0.02, 0.065)
+–+ graduation 196 0 239 215 366
futility 0 0 0 0 0
max_n 2 0 1 2 1
n 5 (2, 14) 18 (12, 24) 5 (2, 14) 5 (2, 14) 7 (2, 18)
n_unique 5 (2, 13) 16 (11, 23) 5 (1, 13) 5 (2, 13) 6 (2, 17)
post_p 0.3 (0.12, 0.58) NA (NA, NA) 0.29 (0.11, 0.59) 0.3 (0.12, 0.56) 0.88 (0.55, 0.98)
rate 0.126 (0.071, 0.333) 0.075 (0.048, 0.117) 0.133 (0.07, 0.388) 0.129 (0.068, 0.389) 0.038 (0.018, 0.075)
+-+- graduation 227 0 260 234 360
futility 0 0 0 0 0
max_n 24 0 19 22 73
n 5 (2, 14) 18 (11, 24) 5 (1, 14) 6 (2, 15) 6 (2, 18)
n_unique 5 (1, 13) 16 (11, 23) 5 (1, 13) 5 (2, 14) 6 (2, 17)
post_p 0.31 (0.12, 0.56) NA (NA, NA) 0.29 (0.13, 0.59) 0.29 (0.12, 0.6) 0.88 (0.52, 0.99)
rate 0.126 (0.074, 0.424) 0.074 (0.051, 0.114) 0.132 (0.068, 0.385) 0.127 (0.068, 0.348) 0.038 (0.017, 0.088)
+-++ graduation 292 0 331 297 415
futility 0 0 0 0 0
max_n 25 0 19 23 71
n 6 (2, 15) 17 (12, 23) 5 (2, 14) 5 (2, 13) 5 (2, 15)
n_unique 5 (1, 14) 16 (10, 22) 4 (1, 12) 5 (2, 13) 5 (1, 15)
post_p 0.31 (0.13, 0.62) NA (NA, NA) 0.3 (0.12, 0.57) 0.3 (0.12, 0.59) 0.88 (0.55, 0.98)
rate 0.122 (0.073, 0.355) 0.075 (0.048, 0.111) 0.125 (0.073, 0.39) 0.129 (0.073, 0.344) 0.036 (0.016, 0.074)
++– graduation 187 0 167 182 303
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 5 (2, 12) 13 (8, 18) 4 (1, 11) 5 (2, 11) 4 (0, 12)
n_unique 4 (2, 11) 12 (7, 17) 4 (1, 10) 4 (2, 10) 4 (0, 11)
post_p 0.32 (0.14, 0.6) NA (NA, NA) 0.35 (0.16, 0.64) 0.32 (0.14, 0.59) 0.8 (0.45, 0.97)
rate 0.13 (0.076, 0.382) 0.075 (0.044, 0.12) 0.126 (0.064, 0.421) 0.128 (0.071, 0.415) 0.038 (0.003, 0.107)
++-+ graduation 260 0 276 272 389
futility 0 0 0 0 0
max_n 2 0 0 2 1
n 5 (2, 11) 12 (7, 19) 4 (1, 11) 5 (2, 13) 2 (0, 10)
n_unique 5 (1, 11) 12 (7, 17) 4 (1, 10) 5 (1, 12) 2 (0, 9)
post_p 0.32 (0.14, 0.61) NA (NA, NA) 0.34 (0.16, 0.65) 0.33 (0.13, 0.63) 0.81 (0.43, 0.97)
rate 0.128 (0.076, 0.411) 0.077 (0.046, 0.13) 0.132 (0.068, 0.359) 0.129 (0.072, 0.377) 0.039 (0, 0.127)
+++- graduation 281 0 286 280 381
futility 0 0 0 0 0
max_n 22 0 19 22 71
n 5 (1, 12) 13 (8, 18) 4 (1, 11) 5 (2, 12) 2 (0, 9)
n_unique 5 (1, 12) 11 (7, 17) 4 (1, 10) 5 (2, 11) 2 (0, 9)
post_p 0.31 (0.13, 0.59) NA (NA, NA) 0.34 (0.15, 0.63) 0.33 (0.15, 0.6) 0.8 (0.45, 0.96)
rate 0.133 (0.076, 0.396) 0.076 (0.048, 0.126) 0.13 (0.068, 0.421) 0.127 (0.075, 0.302) 0.035 (0, 0.114)
++++ graduation 327 0 342 326 423
futility 0 0 0 0 0
max_n 23 0 19 23 69
n 5 (2, 13) 12 (7, 17) 4 (1, 11) 5 (2, 12) 2 (0, 7)
n_unique 5 (1, 12) 11 (7, 16) 4 (0, 10) 5 (1, 11) 2 (0, 7)
post_p 0.32 (0.14, 0.62) NA (NA, NA) 0.35 (0.16, 0.66) 0.31 (0.14, 0.62) 0.78 (0.42, 0.96)
rate 0.13 (0.072, 0.407) 0.076 (0.046, 0.125) 0.135 (0.068, 0.371) 0.136 (0.073, 0.362) 0.04 (0, 0.138)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Niraparib Carboplatin
all count 3 264 1
time_stop 3 (3, 5) 14 (6, 28) 7 (7, 7)
n_trt 27 (27, 34) 86 (37, 202) 31 (31, 31)
n_control 34 (34, 56) 146 (65, 327) 75 (75, 75)
post_p 0.94 (0.9, 0.95) 1 (0.98, 1) 0.88 (0.88, 0.88)
order 1 (1, 1) 2 (1, 3) 1 (1, 1)
TP53- & AR- count 1 375 1 2
time_stop 13 (13, 13) 12 (9, 24) 15 (15, 15) 12 (12, 13)
n_trt 32 (32, 32) 33 (25, 83) 26 (26, 26) 30 (26, 33)
n_control 64 (64, 64) 53 (35, 118) 74 (74, 74) 60 (58, 62)
post_p 0.88 (0.88, 0.88) 0.98 (0.91, 1) 0.97 (0.97, 0.97) 0.93 (0.92, 0.94)
order 3 (3, 3) 1 (1, 3) 4 (4, 4) 4 (4, 4)
TP53+ count 1 278 1
time_stop 7 (7, 7) 14 (8, 29) 10 (10, 10)
n_trt 26 (26, 26) 44 (27, 113) 27 (27, 27)
n_control 26 (26, 26) 64 (36, 156) 51 (51, 51)
post_p 0.93 (0.93, 0.93) 1 (0.95, 1) 0.92 (0.92, 0.92)
order 1 (1, 1) 2 (1, 4) 1 (1, 1)
DRD+ count 1 100
time_stop 15 (15, 15) 24 (16, 33)
n_trt 26 (26, 26) 30 (25, 55)
n_control 41 (41, 41) 66 (41, 101)
post_p 0.86 (0.86, 0.86) 1 (0.98, 1)
order 5 (5, 5) 3 (1, 5)
TEfus+ count 260 1 1
time_stop 15 (10, 29) 12 (12, 12) 10 (10, 10)
n_trt 38 (26, 77) 25 (25, 25) 26 (26, 26)
n_control 60 (35, 126) 49 (49, 49) 42 (42, 42)
post_p 1 (0.97, 1) 0.95 (0.95, 0.95) 0.91 (0.91, 0.91)
order 2 (1, 4) 2 (2, 2) 2 (2, 2)
Futility:
signature var Hormone_therapies Carboplatin Niraparib
all count 100 74 79
time_stop 26 (4, 35) 30 (20, 36) 29 (21, 35)
n_trt 88 (28, 167) 116 (80, 197) 106 (72, 173)
n_control 281 (38, 419) 333 (225, 429) 321 (223, 410)
post_p 0 (0, 0.11) 0 (0, 0.01) 0 (0, 0)
order 5.5 (1, 9) 6 (3.3, 9) 6 (3, 9)
TP53- & AR- count 409 390 403
time_stop 17 (9, 30) 21 (14, 31) 20 (13, 31)
n_trt 37 (25, 87) 40 (25, 93) 37 (25, 93)
n_control 75 (36, 149) 102 (60, 162) 96 (55, 162)
post_p 0.07 (0, 0.23) 0.06 (0, 0.19) 0.06 (0, 0.2)
order 2 (1, 5) 3 (1, 6) 3 (1, 6)
TP53+ count 229 223 231
time_stop 24 (13, 34) 24 (14, 34) 24 (15, 33)
n_trt 49 (28, 109) 49 (28, 95) 49 (27, 89)
n_control 129 (58, 194) 130 (63, 190) 123 (66, 185)
post_p 0.01 (0, 0.09) 0.01 (0, 0.08) 0.01 (0, 0.07)
order 4 (1, 8) 4 (1, 7) 4 (1, 8)
DRD+ count 111 183 175
time_stop 30 (23, 35) 26 (17, 34) 24 (16, 34)
n_trt 37 (26, 58) 43 (29, 67) 39 (27, 57)
n_control 93 (67, 123) 82 (49, 111) 73 (43, 110)
post_p 0.01 (0, 0.06) 0.01 (0, 0.07) 0.01 (0, 0.08)
order 6 (3, 9) 5 (2, 8) 4 (2, 9)
TEfus+ count 198 191 209
time_stop 26 (17, 34) 25 (17, 34) 23 (15, 35)
n_trt 44 (26, 74) 47 (29, 75) 41 (26, 70)
n_control 108 (64, 153) 107 (69, 149) 98 (59, 152)
post_p 0.02 (0, 0.08) 0.01 (0, 0.07) 0.01 (0, 0.06)
order 5 (2, 9) 5 (2, 9) 5 (2, 8)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5) 3 (3, 5)
n 14 (12, 16) 2 (2, 2) 8 (7, 9) 2 (1, 3) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 1) 0 (0, 2) 0 (0, 0) 0 (0, 0) 0 (0, 2) 0 (0, 0)
post_p 0.63 (0.58, 0.73) 0.54 (0.52, 0.56) 0.63 (0.55, 0.7) 0.6 (0.58, 0.61) 0.58 (0.58, 0.58) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA) 0.61 (0.61, 0.61) 0.64 (0.64, 0.64) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.05, 0.083) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 7 (7, 7) 1 (1, 1) 5 (5, 5) 1 (1, 1) 2 (2, 2) 2 (2, 2) 2 (2, 2) 0 (0, 0) 0 (0, 0) 1 (1, 1) 5 (5, 5) 0 (0, 0) 3 (3, 3) 1 (1, 1) 0 (0, 0) 1 (1, 1)
post_p 0.5 (0.5, 0.5) 0.51 (0.51, 0.51) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) 0.64 (0.64, 0.64) 0.69 (0.69, 0.69) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) NA (NA, NA) 0.62 (0.62, 0.62) 0.57 (0.57, 0.57) NA (NA, NA) 0.58 (0.58, 0.58)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.074, 0.074) 0 (0, 0) 0.059 (0.059, 0.059) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.081 (0.081, 0.081) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Taxel_therapies count 264 264 264 264 264 264 264 264 264 264 264 264 264 264 264 264
time 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28) 14 (6, 28)
n 19 (7, 46) 4 (2, 10) 13 (4, 41) 12 (5, 27) 2 (0, 7) 2 (0, 6) 2 (0, 6) 1 (0, 5) 7 (2, 16) 5 (2, 12) 4 (1, 10) 4 (1, 10) 2 (0, 6) 1 (0, 6) 1 (0, 6) 1 (0, 5)
post_p 0.92 (0.62, 1) 0.74 (0.55, 0.95) 0.85 (0.58, 1) 0.8 (0.57, 0.98) 0.66 (0.52, 0.89) 0.68 (0.53, 0.88) 0.66 (0.54, 0.86) 0.63 (0.52, 0.85) 0.75 (0.54, 0.97) 0.68 (0.53, 0.93) 0.67 (0.53, 0.89) 0.69 (0.53, 0.92) 0.64 (0.52, 0.87) 0.64 (0.52, 0.89) 0.63 (0.51, 0.9) 0.66 (0.52, 0.88)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.058) 0.022 (0, 0.072) 0.032 (0, 0.063) 0.035 (0, 0.065) 0 (0, 0.068) 0 (0, 0.075) 0 (0, 0.064) 0 (0, 0.084) 0.028 (0, 0.062) 0.022 (0, 0.069) 0.029 (0, 0.074) 0.023 (0, 0.08) 0 (0, 0.076) 0 (0, 0.071) 0 (0, 0.074) 0 (0, 0.061)
DRD+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 9 (9, 9) 0 (0, 0) 1 (1, 1) 3 (3, 3) 2 (2, 2) 3 (3, 3) 2 (2, 2) 6 (6, 6)
post_p 0.71 (0.71, 0.71) NA (NA, NA) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.71 (0.71, 0.71) 0.56 (0.56, 0.56) 0.72 (0.72, 0.72)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.055 (0.055, 0.055) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.092 (0.092, 0.092) 0.065 (0.065, 0.065) 0.083 (0.083, 0.083) 0.084 (0.084, 0.084)
Taxel_therapies count 100 100 100 100 100 100 100 100
time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
n 4 (1, 11) 4 (1, 11) 4 (1, 9) 2 (0, 7) 4 (1, 10) 3 (1, 8) 3 (0, 9) 3 (0, 7)
post_p 0.77 (0.6, 0.94) 0.77 (0.58, 0.94) 0.74 (0.53, 0.93) 0.73 (0.53, 0.89) 0.73 (0.52, 0.93) 0.75 (0.55, 0.95) 0.75 (0.53, 0.92) 0.72 (0.54, 0.9)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.034 (0, 0.069) 0.034 (0, 0.075) 0.026 (0, 0.09) 0.032 (0, 0.089) 0.02 (0, 0.076) 0.019 (0, 0.061) 0.016 (0, 0.083) 0.03 (0, 0.078)
TEfus+ Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 3 (3, 3) 3 (3, 3) 5 (5, 5) 1 (1, 1) 3 (3, 3) 3 (3, 3) 4 (4, 4) 4 (4, 4)
post_p 0.66 (0.66, 0.66) 0.62 (0.62, 0.62) 0.69 (0.69, 0.69) 0.68 (0.68, 0.68) 0.61 (0.61, 0.61) 0.52 (0.52, 0.52) 0.72 (0.72, 0.72) 0.7 (0.7, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.116 (0.116, 0.116) 0 (0, 0) 0 (0, 0) 0.086 (0.086, 0.086) 0.075 (0.075, 0.075) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 2 (2, 2) 4 (4, 4) 5 (5, 5) 2 (2, 2) 0 (0, 0) 4 (4, 4) 4 (4, 4) 4 (4, 4)
post_p 0.54 (0.54, 0.54) 0.67 (0.67, 0.67) 0.66 (0.66, 0.66) 0.54 (0.54, 0.54) NA (NA, NA) 0.63 (0.63, 0.63) 0.71 (0.71, 0.71) 0.58 (0.58, 0.58)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.042 (0.042, 0.042) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.046 (0.046, 0.046) 0.038 (0.038, 0.038)
Taxel_therapies count 260 260 260 260 260 260 260 260
time 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29) 15 (10, 29)
n 5 (2, 11) 14 (8, 28) 2 (0, 6) 2 (0, 5) 5 (2, 12) 5 (2, 11) 2 (0, 7) 2 (0, 5)
post_p 0.77 (0.57, 0.95) 0.86 (0.73, 1) 0.7 (0.53, 0.89) 0.66 (0.52, 0.88) 0.74 (0.54, 0.93) 0.77 (0.55, 0.93) 0.67 (0.52, 0.92) 0.66 (0.53, 0.87)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.027 (0, 0.064) 0.035 (0.014, 0.063) 0 (0, 0.079) 0 (0, 0.08) 0.031 (0, 0.069) 0.028 (0, 0.071) 0 (0, 0.069) 0 (0, 0.076)
TP53- & AR- Carboplatin count 2 2 2 2
time 12 (12, 13) 12 (12, 13) 12 (12, 13) 12 (12, 13)
n 14 (9, 19) 2 (2, 3) 4 (3, 5) 9 (7, 11)
post_p 0.79 (0.76, 0.81) 0.56 (0.54, 0.59) 0.57 (0.52, 0.61) 0.79 (0.74, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.022 (0.004, 0.04) 0 (0, 0) 0.082 (0.056, 0.109) 0.039 (0.037, 0.041)
Hormone_therapies count 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 23 (23, 23) 5 (5, 5) 4 (4, 4) 0 (0, 0)
post_p 0.83 (0.83, 0.83) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.074 (0.074, 0.074) 0.059 (0.059, 0.059) 0.071 (0.071, 0.071) NA (NA, NA)
Niraparib count 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 16 (16, 16) 1 (1, 1) 5 (5, 5) 4 (4, 4)
post_p 0.78 (0.78, 0.78) 0.54 (0.54, 0.54) 0.84 (0.84, 0.84) 0.53 (0.53, 0.53)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0.072 (0.072, 0.072)
Taxel_therapies count 375 375 375 375
time 12 (9, 24) 12 (9, 24) 12 (9, 24) 12 (9, 24)
n 23 (16, 59) 5 (2, 11) 3 (1, 9) 3 (0, 8)
post_p 0.92 (0.76, 1) 0.74 (0.55, 0.91) 0.64 (0.52, 0.86) 0.64 (0.52, 0.89)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.032 (0.014, 0.051) 0.026 (0, 0.071) 0 (0, 0.074) 0 (0, 0.08)
TP53+ Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 7 (7, 7) 4 (4, 4) 0 (0, 0) 3 (3, 3) 4 (4, 4) 2 (2, 2) 3 (3, 3) 4 (4, 4)
post_p 0.77 (0.77, 0.77) 0.76 (0.76, 0.76) NA (NA, NA) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57) 0.57 (0.57, 0.57) 0.61 (0.61, 0.61) 0.7 (0.7, 0.7)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.062 (0.062, 0.062) 0 (0, 0) NA (NA, NA) 0.095 (0.095, 0.095) 0.047 (0.047, 0.047) 0 (0, 0) 0 (0, 0) 0.101 (0.101, 0.101)
Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 16 (16, 16) 4 (4, 4) 1 (1, 1) 0 (0, 0) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0)
post_p 0.84 (0.84, 0.84) 0.6 (0.6, 0.6) 0.58 (0.58, 0.58) NA (NA, NA) 0.63 (0.63, 0.63) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.031 (0.031, 0.031) 0.064 (0.064, 0.064) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 278 278 278 278 278 278 278 278
time 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29) 14 (8, 29)
n 16 (7, 47) 13 (7, 27) 2 (0, 6) 1 (0, 5) 5 (2, 12) 4 (2, 12) 2 (0, 6) 2 (0, 6)
post_p 0.89 (0.72, 1) 0.85 (0.71, 0.99) 0.64 (0.52, 0.87) 0.63 (0.52, 0.86) 0.73 (0.53, 0.92) 0.75 (0.54, 0.94) 0.63 (0.52, 0.92) 0.68 (0.52, 0.89)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.058) 0.036 (0.011, 0.062) 0 (0, 0.073) 0 (0, 0.071) 0.032 (0, 0.079) 0.024 (0, 0.072) 0 (0, 0.063) 0 (0, 0.072)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74 74
time 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36) 30 (20, 36)
n 21 (9, 63) 5 (2, 15) 12 (5, 39) 8 (3, 19) 7 (3, 17) 7 (2, 17) 4 (1, 9) 4 (1, 8) 4 (2, 12) 4 (1, 11) 3 (1, 9) 4 (1, 11) 4 (2, 9) 4 (1, 10) 4 (1, 8) 4 (2, 8)
post_p 0.1 (0.01, 0.36) 0.29 (0.12, 0.47) 0.19 (0.05, 0.43) 0.19 (0.06, 0.42) 0.27 (0.12, 0.47) 0.29 (0.1, 0.47) 0.33 (0.18, 0.48) 0.31 (0.15, 0.46) 0.28 (0.11, 0.44) 0.29 (0.16, 0.43) 0.29 (0.16, 0.45) 0.32 (0.15, 0.45) 0.32 (0.17, 0.46) 0.32 (0.12, 0.47) 0.29 (0.17, 0.45) 0.29 (0.15, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.095, 0.182) 0.142 (0.086, 0.405) 0.125 (0.087, 0.223) 0.135 (0.093, 0.359) 0.128 (0.084, 0.261) 0.141 (0.091, 0.335) 0.141 (0.09, 0.485) 0.153 (0.101, 0.487) 0.137 (0.082, 0.408) 0.165 (0.09, 0.511) 0.147 (0.09, 0.456) 0.123 (0.088, 0.394) 0.143 (0.084, 0.453) 0.144 (0.086, 0.357) 0.156 (0.08, 0.479) 0.157 (0.09, 0.416)
Hormone_therapies count 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100
time 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35) 26 (4, 35)
n 20 (13, 44) 4 (1, 8) 10 (5, 32) 6 (2, 26) 2 (0, 7) 2 (0, 9) 2 (0, 8) 2 (0, 7) 4 (0, 12) 3 (1, 10) 3 (0, 10) 3 (0, 9) 2 (0, 7) 2 (0, 7) 2 (0, 7) 2 (0, 7)
post_p 0.13 (0.01, 0.41) 0.3 (0.13, 0.45) 0.19 (0.04, 0.43) 0.28 (0.05, 0.46) 0.31 (0.11, 0.42) 0.35 (0.12, 0.46) 0.33 (0.16, 0.47) 0.34 (0.19, 0.48) 0.3 (0.12, 0.45) 0.3 (0.18, 0.48) 0.3 (0.13, 0.47) 0.28 (0.16, 0.46) 0.34 (0.18, 0.45) 0.32 (0.16, 0.49) 0.33 (0.19, 0.44) 0.35 (0.21, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.115 (0.088, 0.16) 0.161 (0.079, 0.455) 0.129 (0.082, 0.248) 0.127 (0.081, 0.396) 0.154 (0.083, 0.556) 0.16 (0.07, 0.384) 0.132 (0.072, 0.436) 0.165 (0.08, 0.537) 0.133 (0.068, 0.411) 0.156 (0.063, 0.607) 0.152 (0.086, 0.548) 0.155 (0.087, 0.451) 0.153 (0.076, 0.606) 0.149 (0.085, 0.693) 0.158 (0.081, 0.522) 0.146 (0.092, 0.516)
Niraparib count 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79 79
time 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35) 29 (21, 35)
n 19 (8, 58) 4 (1, 10) 11 (4, 37) 8 (3, 18) 6 (2, 12) 5 (3, 13) 4 (1, 9) 3 (1, 7) 5 (2, 10) 3 (1, 11) 4 (1, 10) 3 (2, 10) 4 (1, 8) 4 (1, 8) 4 (1, 7) 3 (2, 8)
post_p 0.16 (0.02, 0.39) 0.31 (0.12, 0.43) 0.14 (0.03, 0.4) 0.25 (0.08, 0.46) 0.29 (0.12, 0.46) 0.25 (0.08, 0.47) 0.34 (0.17, 0.48) 0.3 (0.16, 0.44) 0.29 (0.11, 0.46) 0.3 (0.12, 0.44) 0.29 (0.13, 0.46) 0.3 (0.17, 0.48) 0.3 (0.17, 0.46) 0.34 (0.16, 0.47) 0.3 (0.13, 0.46) 0.28 (0.14, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.116 (0.089, 0.165) 0.147 (0.096, 0.492) 0.126 (0.091, 0.28) 0.123 (0.086, 0.286) 0.125 (0.091, 0.307) 0.136 (0.087, 0.349) 0.136 (0.076, 0.408) 0.176 (0.093, 0.465) 0.141 (0.084, 0.325) 0.17 (0.081, 0.559) 0.177 (0.088, 0.533) 0.141 (0.089, 0.387) 0.145 (0.086, 0.485) 0.141 (0.088, 0.555) 0.151 (0.089, 0.41) 0.182 (0.096, 0.773)
DRD+ Carboplatin count 183 183 183 183 183 183 183 183
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 7 (3, 17) 7 (2, 17) 4 (2, 10) 4 (1, 9) 3 (1, 9) 5 (1, 10) 4 (1, 9) 4 (1, 9)
post_p 0.28 (0.09, 0.47) 0.3 (0.11, 0.47) 0.34 (0.16, 0.48) 0.35 (0.16, 0.48) 0.32 (0.14, 0.48) 0.33 (0.14, 0.47) 0.31 (0.17, 0.45) 0.33 (0.15, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.088, 0.308) 0.129 (0.088, 0.288) 0.127 (0.078, 0.334) 0.152 (0.088, 0.477) 0.16 (0.083, 0.548) 0.131 (0.085, 0.347) 0.162 (0.081, 0.487) 0.149 (0.082, 0.47)
Hormone_therapies count 111 111 111 111 111 111 111 111
time 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35) 30 (23, 35)
n 4 (1, 14) 4 (1, 11) 5 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 9) 4 (1, 9) 4 (1, 8)
post_p 0.27 (0.11, 0.41) 0.28 (0.09, 0.45) 0.33 (0.16, 0.47) 0.34 (0.19, 0.46) 0.34 (0.17, 0.47) 0.34 (0.17, 0.47) 0.34 (0.17, 0.47) 0.32 (0.21, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.148 (0.1, 0.596) 0.154 (0.084, 0.423) 0.136 (0.086, 0.497) 0.155 (0.084, 0.701) 0.14 (0.079, 0.564) 0.148 (0.081, 0.44) 0.149 (0.082, 0.517) 0.149 (0.09, 0.404)
Niraparib count 175 175 175 175 175 175 175 175
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 7 (3, 13) 6 (2, 13) 4 (1, 9) 4 (1, 8) 4 (1, 9) 4 (1, 9) 4 (2, 9) 3 (1, 8)
post_p 0.3 (0.11, 0.46) 0.3 (0.1, 0.47) 0.34 (0.18, 0.47) 0.34 (0.17, 0.47) 0.32 (0.17, 0.48) 0.34 (0.16, 0.48) 0.33 (0.17, 0.47) 0.3 (0.16, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.087, 0.25) 0.139 (0.088, 0.37) 0.144 (0.082, 0.457) 0.151 (0.082, 0.521) 0.146 (0.087, 0.564) 0.147 (0.082, 0.517) 0.15 (0.079, 0.365) 0.17 (0.091, 0.483)
TEfus+ Carboplatin count 191 191 191 191 191 191 191 191
time 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34)
n 5 (2, 13) 9 (3, 22) 7 (3, 17) 4 (2, 9) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 9)
post_p 0.31 (0.11, 0.48) 0.23 (0.06, 0.46) 0.32 (0.1, 0.47) 0.34 (0.17, 0.47) 0.33 (0.15, 0.47) 0.32 (0.17, 0.45) 0.32 (0.14, 0.46) 0.31 (0.16, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.136 (0.078, 0.345) 0.127 (0.087, 0.26) 0.128 (0.08, 0.331) 0.146 (0.091, 0.477) 0.138 (0.08, 0.524) 0.133 (0.083, 0.454) 0.143 (0.086, 0.4) 0.15 (0.088, 0.505)
Hormone_therapies count 198 198 198 198 198 198 198 198
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 5 (3, 13) 11 (4, 25) 3 (1, 12) 3 (0, 8) 4 (2, 11) 4 (2, 10) 3 (1, 8) 3 (1, 8)
post_p 0.28 (0.1, 0.46) 0.27 (0.06, 0.46) 0.34 (0.16, 0.45) 0.36 (0.19, 0.48) 0.3 (0.13, 0.46) 0.28 (0.14, 0.47) 0.36 (0.19, 0.47) 0.35 (0.2, 0.47)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.086, 0.302) 0.117 (0.079, 0.226) 0.15 (0.089, 0.419) 0.148 (0.079, 0.562) 0.145 (0.082, 0.372) 0.132 (0.087, 0.45) 0.141 (0.082, 0.415) 0.15 (0.081, 0.43)
Niraparib count 209 209 209 209 209 209 209 209
time 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35) 23 (15, 35)
n 4 (1, 11) 8 (3, 20) 6 (2, 14) 4 (1, 9) 4 (1, 10) 3 (1, 10) 4 (1, 9) 4 (2, 8)
post_p 0.31 (0.14, 0.47) 0.26 (0.1, 0.48) 0.3 (0.1, 0.47) 0.34 (0.17, 0.47) 0.31 (0.14, 0.46) 0.32 (0.16, 0.48) 0.33 (0.15, 0.48) 0.3 (0.14, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.143 (0.086, 0.519) 0.127 (0.079, 0.271) 0.136 (0.08, 0.349) 0.15 (0.086, 0.434) 0.145 (0.076, 0.565) 0.149 (0.084, 0.38) 0.148 (0.082, 0.455) 0.163 (0.091, 0.473)
TP53- & AR- Carboplatin count 390 390 390 390
time 21 (14, 31) 21 (14, 31) 21 (14, 31) 21 (14, 31)
n 20 (8, 60) 5 (2, 12) 7 (3, 16) 7 (3, 17)
post_p 0.19 (0.03, 0.45) 0.35 (0.15, 0.48) 0.32 (0.14, 0.47) 0.34 (0.12, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.112 (0.084, 0.182) 0.131 (0.077, 0.333) 0.128 (0.085, 0.289) 0.127 (0.085, 0.334)
Hormone_therapies count 409 409 409 409
time 17 (9, 30) 17 (9, 30) 17 (9, 30) 17 (9, 30)
n 23 (16, 56) 6 (3, 14) 4 (1, 12) 4 (1, 12)
post_p 0.17 (0.02, 0.39) 0.33 (0.12, 0.47) 0.36 (0.18, 0.48) 0.37 (0.19, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.116 (0.089, 0.159) 0.13 (0.081, 0.289) 0.134 (0.071, 0.554) 0.134 (0.074, 0.428)
Niraparib count 403 403 403 403
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 19 (8, 58) 5 (2, 14) 7 (3, 15) 6 (2, 15)
post_p 0.19 (0.03, 0.44) 0.36 (0.17, 0.47) 0.35 (0.15, 0.48) 0.32 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.086, 0.171) 0.131 (0.079, 0.412) 0.119 (0.078, 0.283) 0.133 (0.085, 0.358)
TP53+ Carboplatin count 223 223 223 223 223 223 223 223
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 11 (5, 36) 9 (3, 25) 4 (2, 10) 4 (2, 9) 4 (1, 10) 4 (1, 11) 4 (1, 8) 4 (1, 8)
post_p 0.21 (0.04, 0.46) 0.27 (0.11, 0.46) 0.34 (0.17, 0.48) 0.35 (0.18, 0.48) 0.31 (0.13, 0.46) 0.35 (0.18, 0.47) 0.32 (0.18, 0.47) 0.32 (0.17, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.086, 0.248) 0.119 (0.087, 0.243) 0.138 (0.076, 0.403) 0.149 (0.086, 0.477) 0.149 (0.083, 0.53) 0.13 (0.08, 0.494) 0.158 (0.083, 0.535) 0.15 (0.088, 0.506)
Hormone_therapies count 229 229 229 229 229 229 229 229
time 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34) 24 (13, 34)
n 14 (7, 44) 9 (4, 28) 3 (1, 9) 3 (0, 8) 4 (2, 12) 4 (2, 11) 3 (1, 8) 3 (1, 9)
post_p 0.18 (0.03, 0.43) 0.24 (0.07, 0.45) 0.35 (0.18, 0.48) 0.35 (0.17, 0.48) 0.33 (0.14, 0.47) 0.31 (0.15, 0.47) 0.34 (0.19, 0.47) 0.36 (0.17, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.088, 0.197) 0.122 (0.084, 0.251) 0.137 (0.074, 0.617) 0.154 (0.083, 0.607) 0.144 (0.084, 0.418) 0.13 (0.076, 0.48) 0.16 (0.078, 0.54) 0.145 (0.084, 0.44)
Niraparib count 231 231 231 231 231 231 231 231
time 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33) 24 (15, 33)
n 12 (4, 37) 8 (3, 19) 4 (1, 9) 4 (1, 8) 4 (1, 10) 3 (1, 10) 4 (2, 8) 3 (1, 9)
post_p 0.19 (0.06, 0.44) 0.25 (0.08, 0.46) 0.35 (0.17, 0.48) 0.33 (0.17, 0.47) 0.34 (0.14, 0.48) 0.33 (0.16, 0.47) 0.34 (0.15, 0.48) 0.31 (0.14, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.121 (0.09, 0.25) 0.131 (0.086, 0.281) 0.136 (0.077, 0.384) 0.157 (0.082, 0.43) 0.145 (0.084, 0.437) 0.14 (0.081, 0.385) 0.145 (0.078, 0.334) 0.174 (0.093, 0.455)