Taxel_therapies more effective in all the biomarker signatures
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 |
|
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The overall error was 0.456.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.012 0.440 0.008 0.006
The overall power was 0.528.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.000 0.528 0.000 0.000
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 0 | 3 | 1 | 264 |
| futility | 74 | 0 | 100 | 79 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 155 (94, 249) | 432 (352, 477) | 139 (80, 225) | 154 (89, 244) | 142 (49, 278) | |
| n_unique | 144 (87, 239) | 401 (329, 445) | 130 (74, 211) | 144 (82, 231) | 132 (45, 259) | |
| time_trial | 36 (33, 36) | 36 (36, 36) | 36 (25, 36) | 36 (31, 36) | 32 (8, 36) | |
| time_stop | 30 (20, 36) | NA (NA, NA) | 25 (4, 35) | 29 (20, 35) | 14 (6, 28) | |
| post_p | 0 (0, 0.01) | NA (NA, NA) | 0 (0, 0.01) | 0 (0, 0.01) | 1 (1, 1) | |
| rate | 0.113 (0.101, 0.129) | 0.075 (0.069, 0.081) | 0.114 (0.101, 0.131) | 0.113 (0.102, 0.13) | 0.036 (0.031, 0.041) | |
| DRD+ | graduation | 0 | 0 | 1 | 0 | 100 |
| futility | 183 | 0 | 111 | 175 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 55 (33, 80) | 112 (90, 133) | 41 (19, 69) | 53 (29, 83) | 26 (5, 59) | |
| n_unique | 51 (30, 76) | 105 (83, 123) | 38 (17, 63) | 49 (27, 78) | 24 (5, 56) | |
| time_trial | 36 (22, 36) | 36 (36, 36) | 36 (29, 36) | 36 (20, 36) | 36 (24, 36) | |
| time_stop | 26 (17, 34) | NA (NA, NA) | 30 (23, 35) | 24 (16, 34) | 24 (16, 33) | |
| post_p | 0.02 (0, 0.15) | NA (NA, NA) | 0.04 (0, 0.26) | 0.02 (0, 0.16) | 1 (0.87, 1) | |
| rate | 0.116 (0.096, 0.141) | 0.075 (0.064, 0.086) | 0.114 (0.093, 0.156) | 0.114 (0.096, 0.145) | 0.036 (0.023, 0.051) | |
| TEfus+ | graduation | 1 | 0 | 0 | 1 | 260 |
| futility | 191 | 0 | 198 | 209 | 0 | |
| max_n | 2 | 0 | 1 | 2 | 1 | |
| n | 62 (33, 101) | 155 (127, 178) | 54 (25, 91) | 59 (30, 105) | 43 (20, 103) | |
| n_unique | 57 (31, 95) | 144 (118, 167) | 50 (23, 85) | 54 (27, 96) | 39 (18, 97) | |
| time_trial | 36 (20, 36) | 36 (36, 36) | 36 (21, 36) | 36 (18, 36) | 33 (11, 36) | |
| time_stop | 25 (17, 34) | NA (NA, NA) | 26 (17, 34) | 23 (15, 35) | 15 (10, 29) | |
| post_p | 0.02 (0, 0.15) | NA (NA, NA) | 0.02 (0, 0.16) | 0.01 (0, 0.13) | 1 (0.99, 1) | |
| rate | 0.113 (0.096, 0.138) | 0.075 (0.066, 0.085) | 0.115 (0.096, 0.144) | 0.115 (0.097, 0.145) | 0.037 (0.028, 0.045) | |
| TP53- & AR- | graduation | 2 | 0 | 1 | 1 | 375 |
| futility | 390 | 0 | 409 | 403 | 0 | |
| max_n | 30 | 0 | 5 | 17 | 14 | |
| n | 47 (26, 136) | 166 (99, 203) | 39 (25, 105) | 42 (25, 123) | 31 (18, 116) | |
| n_unique | 43 (24, 130) | 155 (92, 191) | 37 (23, 101) | 40 (24, 118) | 29 (15, 111) | |
| time_trial | 23 (15, 36) | 36 (36, 36) | 19 (9, 36) | 22 (13, 36) | 15 (9, 36) | |
| time_stop | 21 (14, 31) | NA (NA, NA) | 17 (9, 30) | 20 (13, 31) | 12 (9, 24) | |
| post_p | 0.02 (0, 0.13) | NA (NA, NA) | 0.02 (0, 0.13) | 0.02 (0, 0.14) | 1 (0.98, 1) | |
| rate | 0.114 (0.098, 0.145) | 0.075 (0.066, 0.085) | 0.117 (0.098, 0.151) | 0.115 (0.098, 0.142) | 0.036 (0.027, 0.046) | |
| TP53+ | graduation | 1 | 0 | 1 | 0 | 278 |
| futility | 223 | 0 | 229 | 231 | 0 | |
| max_n | 24 | 0 | 19 | 22 | 77 | |
| n | 71 (35, 127) | 200 (173, 226) | 66 (27, 120) | 70 (32, 132) | 59 (25, 152) | |
| n_unique | 66 (32, 118) | 188 (162, 210) | 61 (26, 114) | 65 (30, 123) | 56 (22, 143) | |
| time_trial | 36 (18, 36) | 36 (36, 36) | 36 (17, 36) | 36 (17, 36) | 30 (9, 36) | |
| time_stop | 24 (13, 34) | NA (NA, NA) | 24 (13, 34) | 24 (15, 33) | 14 (8, 29) | |
| post_p | 0.01 (0, 0.09) | NA (NA, NA) | 0.01 (0, 0.11) | 0.01 (0, 0.09) | 1 (0.99, 1) | |
| rate | 0.114 (0.098, 0.137) | 0.075 (0.067, 0.084) | 0.114 (0.096, 0.142) | 0.114 (0.099, 0.142) | 0.036 (0.029, 0.044) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 396 | 0 | 442 | 412 | 464 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 30 | 0 | 5 | 17 | 14 | |
| n | 24 (9, 86) | 108 (63, 135) | 23 (15, 67) | 21 (8, 83) | 22 (10, 83) | |
| n_unique | 22 (8, 83) | 101 (57, 127) | 22 (14, 66) | 20 (7, 79) | 21 (10, 80) | |
| post_p | 0.08 (0, 0.3) | NA (NA, NA) | 0.06 (0, 0.26) | 0.07 (0, 0.33) | 1 (0.92, 1) | |
| rate | 0.115 (0.093, 0.173) | 0.075 (0.064, 0.087) | 0.117 (0.093, 0.157) | 0.115 (0.091, 0.173) | 0.035 (0.026, 0.049) | |
| —+ | graduation | 410 | 0 | 457 | 429 | 469 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 31 | 0 | 5 | 19 | 14 | |
| n | 6 (2, 16) | 18 (10, 27) | 6 (2, 15) | 5 (2, 17) | 5 (2, 12) | |
| n_unique | 5 (2, 16) | 17 (9, 25) | 5 (2, 14) | 5 (1, 16) | 5 (2, 11) | |
| post_p | 0.28 (0.11, 0.62) | NA (NA, NA) | 0.26 (0.09, 0.54) | 0.28 (0.1, 0.58) | 0.87 (0.53, 0.99) | |
| rate | 0.126 (0.073, 0.283) | 0.074 (0.05, 0.111) | 0.134 (0.082, 0.304) | 0.13 (0.076, 0.392) | 0.037 (0.017, 0.079) | |
| –+- | graduation | 227 | 0 | 260 | 234 | 360 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 24 | 0 | 19 | 22 | 73 | |
| n | 16 (5, 51) | 69 (57, 83) | 16 (7, 51) | 15 (5, 52) | 22 (6, 63) | |
| n_unique | 15 (5, 49) | 66 (54, 78) | 15 (6, 49) | 14 (5, 49) | 21 (5, 61) | |
| post_p | 0.12 (0.03, 0.44) | NA (NA, NA) | 0.12 (0.02, 0.36) | 0.13 (0.02, 0.41) | 1 (0.83, 1) | |
| rate | 0.121 (0.088, 0.211) | 0.076 (0.062, 0.092) | 0.12 (0.091, 0.196) | 0.12 (0.089, 0.23) | 0.036 (0.023, 0.054) | |
| –++ | graduation | 292 | 0 | 331 | 297 | 415 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 25 | 0 | 19 | 23 | 71 | |
| n | 11 (4, 33) | 46 (33, 56) | 12 (4, 33) | 10 (4, 34) | 14 (6, 40) | |
| n_unique | 10 (3, 32) | 43 (31, 54) | 11 (3, 31) | 9 (3, 32) | 13 (5, 37) | |
| post_p | 0.2 (0.04, 0.51) | NA (NA, NA) | 0.19 (0.05, 0.47) | 0.18 (0.04, 0.46) | 0.98 (0.76, 1) | |
| rate | 0.121 (0.082, 0.22) | 0.076 (0.06, 0.096) | 0.119 (0.084, 0.239) | 0.125 (0.086, 0.241) | 0.038 (0.023, 0.058) | |
| -+– | graduation | 414 | 0 | 449 | 425 | 467 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 30 | 0 | 5 | 17 | 14 | |
| n | 8 (3, 20) | 19 (10, 27) | 4 (0, 14) | 8 (3, 19) | 3 (0, 11) | |
| n_unique | 7 (3, 19) | 17 (8, 26) | 4 (0, 14) | 7 (2, 18) | 2 (0, 10) | |
| post_p | 0.27 (0.09, 0.54) | NA (NA, NA) | 0.3 (0.12, 0.57) | 0.26 (0.09, 0.54) | 0.8 (0.48, 0.97) | |
| rate | 0.124 (0.079, 0.265) | 0.074 (0.051, 0.107) | 0.137 (0.077, 0.494) | 0.121 (0.08, 0.244) | 0.039 (0.008, 0.091) | |
| -+-+ | graduation | 423 | 0 | 465 | 438 | 472 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 31 | 0 | 4 | 19 | 14 | |
| n | 8 (3, 20) | 17 (9, 27) | 4 (0, 13) | 6 (2, 19) | 3 (0, 9) | |
| n_unique | 8 (3, 19) | 16 (8, 25) | 4 (0, 13) | 6 (2, 17) | 2 (0, 8) | |
| post_p | 0.29 (0.1, 0.61) | NA (NA, NA) | 0.31 (0.14, 0.59) | 0.27 (0.09, 0.59) | 0.82 (0.48, 0.98) | |
| rate | 0.12 (0.078, 0.29) | 0.078 (0.051, 0.113) | 0.136 (0.079, 0.411) | 0.128 (0.082, 0.347) | 0.039 (0, 0.101) | |
| -++- | graduation | 281 | 0 | 286 | 280 | 381 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 22 | 0 | 19 | 22 | 71 | |
| n | 5 (2, 12) | 13 (8, 18) | 4 (1, 11) | 5 (2, 12) | 2 (0, 9) | |
| n_unique | 5 (2, 12) | 12 (7, 17) | 4 (1, 10) | 5 (1, 11) | 2 (0, 9) | |
| post_p | 0.31 (0.14, 0.62) | NA (NA, NA) | 0.34 (0.16, 0.61) | 0.32 (0.15, 0.6) | 0.77 (0.4, 0.95) | |
| rate | 0.127 (0.073, 0.316) | 0.075 (0.048, 0.118) | 0.127 (0.072, 0.395) | 0.125 (0.07, 0.336) | 0.041 (0, 0.14) | |
| -+++ | graduation | 327 | 0 | 342 | 326 | 423 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 23 | 0 | 19 | 23 | 69 | |
| n | 5 (2, 13) | 12 (7, 17) | 4 (0, 10) | 5 (1, 13) | 2 (0, 7) | |
| n_unique | 5 (1, 12) | 11 (6, 16) | 3 (0, 10) | 5 (1, 12) | 2 (0, 7) | |
| post_p | 0.32 (0.14, 0.59) | NA (NA, NA) | 0.35 (0.16, 0.65) | 0.32 (0.15, 0.66) | 0.77 (0.41, 0.95) | |
| rate | 0.134 (0.079, 0.39) | 0.078 (0.046, 0.125) | 0.132 (0.072, 0.494) | 0.134 (0.073, 0.348) | 0.041 (0, 0.119) | |
| +— | graduation | 74 | 0 | 103 | 80 | 264 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 15) | 22 (15, 28) | 5 (2, 16) | 6 (2, 15) | 13 (3, 26) | |
| n_unique | 5 (2, 15) | 20 (14, 27) | 5 (2, 14) | 5 (2, 14) | 12 (3, 24) | |
| post_p | 0.28 (0.1, 0.58) | NA (NA, NA) | 0.26 (0.11, 0.57) | 0.28 (0.11, 0.54) | 0.94 (0.64, 1) | |
| rate | 0.128 (0.073, 0.373) | 0.076 (0.053, 0.106) | 0.129 (0.075, 0.363) | 0.128 (0.073, 0.313) | 0.035 (0.02, 0.065) | |
| +–+ | graduation | 196 | 0 | 239 | 215 | 366 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 2 | 0 | 1 | 2 | 1 | |
| n | 5 (2, 14) | 18 (12, 24) | 5 (2, 14) | 5 (2, 14) | 7 (2, 18) | |
| n_unique | 5 (2, 13) | 16 (11, 23) | 5 (1, 13) | 5 (2, 13) | 6 (2, 17) | |
| post_p | 0.3 (0.12, 0.58) | NA (NA, NA) | 0.29 (0.11, 0.59) | 0.3 (0.12, 0.56) | 0.88 (0.55, 0.98) | |
| rate | 0.126 (0.071, 0.333) | 0.075 (0.048, 0.117) | 0.133 (0.07, 0.388) | 0.129 (0.068, 0.389) | 0.038 (0.018, 0.075) | |
| +-+- | graduation | 227 | 0 | 260 | 234 | 360 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 24 | 0 | 19 | 22 | 73 | |
| n | 5 (2, 14) | 18 (11, 24) | 5 (1, 14) | 6 (2, 15) | 6 (2, 18) | |
| n_unique | 5 (1, 13) | 16 (11, 23) | 5 (1, 13) | 5 (2, 14) | 6 (2, 17) | |
| post_p | 0.31 (0.12, 0.56) | NA (NA, NA) | 0.29 (0.13, 0.59) | 0.29 (0.12, 0.6) | 0.88 (0.52, 0.99) | |
| rate | 0.126 (0.074, 0.424) | 0.074 (0.051, 0.114) | 0.132 (0.068, 0.385) | 0.127 (0.068, 0.348) | 0.038 (0.017, 0.088) | |
| +-++ | graduation | 292 | 0 | 331 | 297 | 415 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 25 | 0 | 19 | 23 | 71 | |
| n | 6 (2, 15) | 17 (12, 23) | 5 (2, 14) | 5 (2, 13) | 5 (2, 15) | |
| n_unique | 5 (1, 14) | 16 (10, 22) | 4 (1, 12) | 5 (2, 13) | 5 (1, 15) | |
| post_p | 0.31 (0.13, 0.62) | NA (NA, NA) | 0.3 (0.12, 0.57) | 0.3 (0.12, 0.59) | 0.88 (0.55, 0.98) | |
| rate | 0.122 (0.073, 0.355) | 0.075 (0.048, 0.111) | 0.125 (0.073, 0.39) | 0.129 (0.073, 0.344) | 0.036 (0.016, 0.074) | |
| ++– | graduation | 187 | 0 | 167 | 182 | 303 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 5 (2, 12) | 13 (8, 18) | 4 (1, 11) | 5 (2, 11) | 4 (0, 12) | |
| n_unique | 4 (2, 11) | 12 (7, 17) | 4 (1, 10) | 4 (2, 10) | 4 (0, 11) | |
| post_p | 0.32 (0.14, 0.6) | NA (NA, NA) | 0.35 (0.16, 0.64) | 0.32 (0.14, 0.59) | 0.8 (0.45, 0.97) | |
| rate | 0.13 (0.076, 0.382) | 0.075 (0.044, 0.12) | 0.126 (0.064, 0.421) | 0.128 (0.071, 0.415) | 0.038 (0.003, 0.107) | |
| ++-+ | graduation | 260 | 0 | 276 | 272 | 389 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 2 | 0 | 0 | 2 | 1 | |
| n | 5 (2, 11) | 12 (7, 19) | 4 (1, 11) | 5 (2, 13) | 2 (0, 10) | |
| n_unique | 5 (1, 11) | 12 (7, 17) | 4 (1, 10) | 5 (1, 12) | 2 (0, 9) | |
| post_p | 0.32 (0.14, 0.61) | NA (NA, NA) | 0.34 (0.16, 0.65) | 0.33 (0.13, 0.63) | 0.81 (0.43, 0.97) | |
| rate | 0.128 (0.076, 0.411) | 0.077 (0.046, 0.13) | 0.132 (0.068, 0.359) | 0.129 (0.072, 0.377) | 0.039 (0, 0.127) | |
| +++- | graduation | 281 | 0 | 286 | 280 | 381 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 22 | 0 | 19 | 22 | 71 | |
| n | 5 (1, 12) | 13 (8, 18) | 4 (1, 11) | 5 (2, 12) | 2 (0, 9) | |
| n_unique | 5 (1, 12) | 11 (7, 17) | 4 (1, 10) | 5 (2, 11) | 2 (0, 9) | |
| post_p | 0.31 (0.13, 0.59) | NA (NA, NA) | 0.34 (0.15, 0.63) | 0.33 (0.15, 0.6) | 0.8 (0.45, 0.96) | |
| rate | 0.133 (0.076, 0.396) | 0.076 (0.048, 0.126) | 0.13 (0.068, 0.421) | 0.127 (0.075, 0.302) | 0.035 (0, 0.114) | |
| ++++ | graduation | 327 | 0 | 342 | 326 | 423 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 23 | 0 | 19 | 23 | 69 | |
| n | 5 (2, 13) | 12 (7, 17) | 4 (1, 11) | 5 (2, 12) | 2 (0, 7) | |
| n_unique | 5 (1, 12) | 11 (7, 16) | 4 (0, 10) | 5 (1, 11) | 2 (0, 7) | |
| post_p | 0.32 (0.14, 0.62) | NA (NA, NA) | 0.35 (0.16, 0.66) | 0.31 (0.14, 0.62) | 0.78 (0.42, 0.96) | |
| rate | 0.13 (0.072, 0.407) | 0.076 (0.046, 0.125) | 0.135 (0.068, 0.371) | 0.136 (0.073, 0.362) | 0.04 (0, 0.138) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib | Carboplatin |
|---|---|---|---|---|---|
| all | count | 3 | 264 | 1 | |
| time_stop | 3 (3, 5) | 14 (6, 28) | 7 (7, 7) | ||
| n_trt | 27 (27, 34) | 86 (37, 202) | 31 (31, 31) | ||
| n_control | 34 (34, 56) | 146 (65, 327) | 75 (75, 75) | ||
| post_p | 0.94 (0.9, 0.95) | 1 (0.98, 1) | 0.88 (0.88, 0.88) | ||
| order | 1 (1, 1) | 2 (1, 3) | 1 (1, 1) | ||
| TP53- & AR- | count | 1 | 375 | 1 | 2 |
| time_stop | 13 (13, 13) | 12 (9, 24) | 15 (15, 15) | 12 (12, 13) | |
| n_trt | 32 (32, 32) | 33 (25, 83) | 26 (26, 26) | 30 (26, 33) | |
| n_control | 64 (64, 64) | 53 (35, 118) | 74 (74, 74) | 60 (58, 62) | |
| post_p | 0.88 (0.88, 0.88) | 0.98 (0.91, 1) | 0.97 (0.97, 0.97) | 0.93 (0.92, 0.94) | |
| order | 3 (3, 3) | 1 (1, 3) | 4 (4, 4) | 4 (4, 4) | |
| TP53+ | count | 1 | 278 | 1 | |
| time_stop | 7 (7, 7) | 14 (8, 29) | 10 (10, 10) | ||
| n_trt | 26 (26, 26) | 44 (27, 113) | 27 (27, 27) | ||
| n_control | 26 (26, 26) | 64 (36, 156) | 51 (51, 51) | ||
| post_p | 0.93 (0.93, 0.93) | 1 (0.95, 1) | 0.92 (0.92, 0.92) | ||
| order | 1 (1, 1) | 2 (1, 4) | 1 (1, 1) | ||
| DRD+ | count | 1 | 100 | ||
| time_stop | 15 (15, 15) | 24 (16, 33) | |||
| n_trt | 26 (26, 26) | 30 (25, 55) | |||
| n_control | 41 (41, 41) | 66 (41, 101) | |||
| post_p | 0.86 (0.86, 0.86) | 1 (0.98, 1) | |||
| order | 5 (5, 5) | 3 (1, 5) | |||
| TEfus+ | count | 260 | 1 | 1 | |
| time_stop | 15 (10, 29) | 12 (12, 12) | 10 (10, 10) | ||
| n_trt | 38 (26, 77) | 25 (25, 25) | 26 (26, 26) | ||
| n_control | 60 (35, 126) | 49 (49, 49) | 42 (42, 42) | ||
| post_p | 1 (0.97, 1) | 0.95 (0.95, 0.95) | 0.91 (0.91, 0.91) | ||
| order | 2 (1, 4) | 2 (2, 2) | 2 (2, 2) |
| signature | var | Hormone_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|
| all | count | 100 | 74 | 79 |
| time_stop | 26 (4, 35) | 30 (20, 36) | 29 (21, 35) | |
| n_trt | 88 (28, 167) | 116 (80, 197) | 106 (72, 173) | |
| n_control | 281 (38, 419) | 333 (225, 429) | 321 (223, 410) | |
| post_p | 0 (0, 0.11) | 0 (0, 0.01) | 0 (0, 0) | |
| order | 5.5 (1, 9) | 6 (3.3, 9) | 6 (3, 9) | |
| TP53- & AR- | count | 409 | 390 | 403 |
| time_stop | 17 (9, 30) | 21 (14, 31) | 20 (13, 31) | |
| n_trt | 37 (25, 87) | 40 (25, 93) | 37 (25, 93) | |
| n_control | 75 (36, 149) | 102 (60, 162) | 96 (55, 162) | |
| post_p | 0.07 (0, 0.23) | 0.06 (0, 0.19) | 0.06 (0, 0.2) | |
| order | 2 (1, 5) | 3 (1, 6) | 3 (1, 6) | |
| TP53+ | count | 229 | 223 | 231 |
| time_stop | 24 (13, 34) | 24 (14, 34) | 24 (15, 33) | |
| n_trt | 49 (28, 109) | 49 (28, 95) | 49 (27, 89) | |
| n_control | 129 (58, 194) | 130 (63, 190) | 123 (66, 185) | |
| post_p | 0.01 (0, 0.09) | 0.01 (0, 0.08) | 0.01 (0, 0.07) | |
| order | 4 (1, 8) | 4 (1, 7) | 4 (1, 8) | |
| DRD+ | count | 111 | 183 | 175 |
| time_stop | 30 (23, 35) | 26 (17, 34) | 24 (16, 34) | |
| n_trt | 37 (26, 58) | 43 (29, 67) | 39 (27, 57) | |
| n_control | 93 (67, 123) | 82 (49, 111) | 73 (43, 110) | |
| post_p | 0.01 (0, 0.06) | 0.01 (0, 0.07) | 0.01 (0, 0.08) | |
| order | 6 (3, 9) | 5 (2, 8) | 4 (2, 9) | |
| TEfus+ | count | 198 | 191 | 209 |
| time_stop | 26 (17, 34) | 25 (17, 34) | 23 (15, 35) | |
| n_trt | 44 (26, 74) | 47 (29, 75) | 41 (26, 70) | |
| n_control | 108 (64, 153) | 107 (69, 149) | 98 (59, 152) | |
| post_p | 0.02 (0, 0.08) | 0.01 (0, 0.07) | 0.01 (0, 0.06) | |
| order | 5 (2, 9) | 5 (2, 9) | 5 (2, 8) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| time | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | 3 (3, 5) | ||
| n | 14 (12, 16) | 2 (2, 2) | 8 (7, 9) | 2 (1, 3) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 2) | 0 (0, 1) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | ||
| post_p | 0.63 (0.58, 0.73) | 0.54 (0.52, 0.56) | 0.63 (0.55, 0.7) | 0.6 (0.58, 0.61) | 0.58 (0.58, 0.58) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | 0.61 (0.61, 0.61) | 0.64 (0.64, 0.64) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.076 (0.05, 0.083) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||
| n | 7 (7, 7) | 1 (1, 1) | 5 (5, 5) | 1 (1, 1) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 5 (5, 5) | 0 (0, 0) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | 1 (1, 1) | ||
| post_p | 0.5 (0.5, 0.5) | 0.51 (0.51, 0.51) | 0.55 (0.55, 0.55) | 0.54 (0.54, 0.54) | 0.64 (0.64, 0.64) | 0.69 (0.69, 0.69) | 0.61 (0.61, 0.61) | NA (NA, NA) | NA (NA, NA) | 0.56 (0.56, 0.56) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.62 (0.62, 0.62) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.58 (0.58, 0.58) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.074 (0.074, 0.074) | 0 (0, 0) | 0.059 (0.059, 0.059) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.081 (0.081, 0.081) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | ||
| Taxel_therapies | count | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | 264 | |
| time | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | 14 (6, 28) | ||
| n | 19 (7, 46) | 4 (2, 10) | 13 (4, 41) | 12 (5, 27) | 2 (0, 7) | 2 (0, 6) | 2 (0, 6) | 1 (0, 5) | 7 (2, 16) | 5 (2, 12) | 4 (1, 10) | 4 (1, 10) | 2 (0, 6) | 1 (0, 6) | 1 (0, 6) | 1 (0, 5) | ||
| post_p | 0.92 (0.62, 1) | 0.74 (0.55, 0.95) | 0.85 (0.58, 1) | 0.8 (0.57, 0.98) | 0.66 (0.52, 0.89) | 0.68 (0.53, 0.88) | 0.66 (0.54, 0.86) | 0.63 (0.52, 0.85) | 0.75 (0.54, 0.97) | 0.68 (0.53, 0.93) | 0.67 (0.53, 0.89) | 0.69 (0.53, 0.92) | 0.64 (0.52, 0.87) | 0.64 (0.52, 0.89) | 0.63 (0.51, 0.9) | 0.66 (0.52, 0.88) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.033 (0, 0.058) | 0.022 (0, 0.072) | 0.032 (0, 0.063) | 0.035 (0, 0.065) | 0 (0, 0.068) | 0 (0, 0.075) | 0 (0, 0.064) | 0 (0, 0.084) | 0.028 (0, 0.062) | 0.022 (0, 0.069) | 0.029 (0, 0.074) | 0.023 (0, 0.08) | 0 (0, 0.076) | 0 (0, 0.071) | 0 (0, 0.074) | 0 (0, 0.061) | ||
| DRD+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||
| n | 9 (9, 9) | 0 (0, 0) | 1 (1, 1) | 3 (3, 3) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | 6 (6, 6) | ||||||||||
| post_p | 0.71 (0.71, 0.71) | NA (NA, NA) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.71 (0.71, 0.71) | 0.56 (0.56, 0.56) | 0.72 (0.72, 0.72) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.055 (0.055, 0.055) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.092 (0.092, 0.092) | 0.065 (0.065, 0.065) | 0.083 (0.083, 0.083) | 0.084 (0.084, 0.084) | ||||||||||
| Taxel_therapies | count | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |||||||||
| time | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | 24 (16, 33) | ||||||||||
| n | 4 (1, 11) | 4 (1, 11) | 4 (1, 9) | 2 (0, 7) | 4 (1, 10) | 3 (1, 8) | 3 (0, 9) | 3 (0, 7) | ||||||||||
| post_p | 0.77 (0.6, 0.94) | 0.77 (0.58, 0.94) | 0.74 (0.53, 0.93) | 0.73 (0.53, 0.89) | 0.73 (0.52, 0.93) | 0.75 (0.55, 0.95) | 0.75 (0.53, 0.92) | 0.72 (0.54, 0.9) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.034 (0, 0.069) | 0.034 (0, 0.075) | 0.026 (0, 0.09) | 0.032 (0, 0.089) | 0.02 (0, 0.076) | 0.019 (0, 0.061) | 0.016 (0, 0.083) | 0.03 (0, 0.078) | ||||||||||
| TEfus+ | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 3 (3, 3) | 3 (3, 3) | 5 (5, 5) | 1 (1, 1) | 3 (3, 3) | 3 (3, 3) | 4 (4, 4) | 4 (4, 4) | ||||||||||
| post_p | 0.66 (0.66, 0.66) | 0.62 (0.62, 0.62) | 0.69 (0.69, 0.69) | 0.68 (0.68, 0.68) | 0.61 (0.61, 0.61) | 0.52 (0.52, 0.52) | 0.72 (0.72, 0.72) | 0.7 (0.7, 0.7) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0.116 (0.116, 0.116) | 0 (0, 0) | 0 (0, 0) | 0.086 (0.086, 0.086) | 0.075 (0.075, 0.075) | 0 (0, 0) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||||||||||
| n | 2 (2, 2) | 4 (4, 4) | 5 (5, 5) | 2 (2, 2) | 0 (0, 0) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||||||||||
| post_p | 0.54 (0.54, 0.54) | 0.67 (0.67, 0.67) | 0.66 (0.66, 0.66) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.63 (0.63, 0.63) | 0.71 (0.71, 0.71) | 0.58 (0.58, 0.58) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0.042 (0.042, 0.042) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.046 (0.046, 0.046) | 0.038 (0.038, 0.038) | ||||||||||
| Taxel_therapies | count | 260 | 260 | 260 | 260 | 260 | 260 | 260 | 260 | |||||||||
| time | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | 15 (10, 29) | ||||||||||
| n | 5 (2, 11) | 14 (8, 28) | 2 (0, 6) | 2 (0, 5) | 5 (2, 12) | 5 (2, 11) | 2 (0, 7) | 2 (0, 5) | ||||||||||
| post_p | 0.77 (0.57, 0.95) | 0.86 (0.73, 1) | 0.7 (0.53, 0.89) | 0.66 (0.52, 0.88) | 0.74 (0.54, 0.93) | 0.77 (0.55, 0.93) | 0.67 (0.52, 0.92) | 0.66 (0.53, 0.87) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.027 (0, 0.064) | 0.035 (0.014, 0.063) | 0 (0, 0.079) | 0 (0, 0.08) | 0.031 (0, 0.069) | 0.028 (0, 0.071) | 0 (0, 0.069) | 0 (0, 0.076) | ||||||||||
| TP53- & AR- | Carboplatin | count | 2 | 2 | 2 | 2 | ||||||||||||
| time | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | 12 (12, 13) | ||||||||||||||
| n | 14 (9, 19) | 2 (2, 3) | 4 (3, 5) | 9 (7, 11) | ||||||||||||||
| post_p | 0.79 (0.76, 0.81) | 0.56 (0.54, 0.59) | 0.57 (0.52, 0.61) | 0.79 (0.74, 0.85) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.022 (0.004, 0.04) | 0 (0, 0) | 0.082 (0.056, 0.109) | 0.039 (0.037, 0.041) | ||||||||||||||
| Hormone_therapies | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||||||
| n | 23 (23, 23) | 5 (5, 5) | 4 (4, 4) | 0 (0, 0) | ||||||||||||||
| post_p | 0.83 (0.83, 0.83) | 0.54 (0.54, 0.54) | 0.56 (0.56, 0.56) | NA (NA, NA) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.074 (0.074, 0.074) | 0.059 (0.059, 0.059) | 0.071 (0.071, 0.071) | NA (NA, NA) | ||||||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | 15 (15, 15) | ||||||||||||||
| n | 16 (16, 16) | 1 (1, 1) | 5 (5, 5) | 4 (4, 4) | ||||||||||||||
| post_p | 0.78 (0.78, 0.78) | 0.54 (0.54, 0.54) | 0.84 (0.84, 0.84) | 0.53 (0.53, 0.53) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.053 (0.053, 0.053) | 0 (0, 0) | 0 (0, 0) | 0.072 (0.072, 0.072) | ||||||||||||||
| Taxel_therapies | count | 375 | 375 | 375 | 375 | |||||||||||||
| time | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | 12 (9, 24) | ||||||||||||||
| n | 23 (16, 59) | 5 (2, 11) | 3 (1, 9) | 3 (0, 8) | ||||||||||||||
| post_p | 0.92 (0.76, 1) | 0.74 (0.55, 0.91) | 0.64 (0.52, 0.86) | 0.64 (0.52, 0.89) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.032 (0.014, 0.051) | 0.026 (0, 0.071) | 0 (0, 0.074) | 0 (0, 0.08) | ||||||||||||||
| TP53+ | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 7 (7, 7) | 4 (4, 4) | 0 (0, 0) | 3 (3, 3) | 4 (4, 4) | 2 (2, 2) | 3 (3, 3) | 4 (4, 4) | ||||||||||
| post_p | 0.77 (0.77, 0.77) | 0.76 (0.76, 0.76) | NA (NA, NA) | 0.56 (0.56, 0.56) | 0.57 (0.57, 0.57) | 0.57 (0.57, 0.57) | 0.61 (0.61, 0.61) | 0.7 (0.7, 0.7) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.062 (0.062, 0.062) | 0 (0, 0) | NA (NA, NA) | 0.095 (0.095, 0.095) | 0.047 (0.047, 0.047) | 0 (0, 0) | 0 (0, 0) | 0.101 (0.101, 0.101) | ||||||||||
| Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||||||||||
| n | 16 (16, 16) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 2 (2, 2) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| post_p | 0.84 (0.84, 0.84) | 0.6 (0.6, 0.6) | 0.58 (0.58, 0.58) | NA (NA, NA) | 0.63 (0.63, 0.63) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.031 (0.031, 0.031) | 0.064 (0.064, 0.064) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| Taxel_therapies | count | 278 | 278 | 278 | 278 | 278 | 278 | 278 | 278 | |||||||||
| time | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | 14 (8, 29) | ||||||||||
| n | 16 (7, 47) | 13 (7, 27) | 2 (0, 6) | 1 (0, 5) | 5 (2, 12) | 4 (2, 12) | 2 (0, 6) | 2 (0, 6) | ||||||||||
| post_p | 0.89 (0.72, 1) | 0.85 (0.71, 0.99) | 0.64 (0.52, 0.87) | 0.63 (0.52, 0.86) | 0.73 (0.53, 0.92) | 0.75 (0.54, 0.94) | 0.63 (0.52, 0.92) | 0.68 (0.52, 0.89) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.033 (0, 0.058) | 0.036 (0.011, 0.062) | 0 (0, 0.073) | 0 (0, 0.071) | 0.032 (0, 0.079) | 0.024 (0, 0.072) | 0 (0, 0.063) | 0 (0, 0.072) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 |
| time | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | 30 (20, 36) | ||
| n | 21 (9, 63) | 5 (2, 15) | 12 (5, 39) | 8 (3, 19) | 7 (3, 17) | 7 (2, 17) | 4 (1, 9) | 4 (1, 8) | 4 (2, 12) | 4 (1, 11) | 3 (1, 9) | 4 (1, 11) | 4 (2, 9) | 4 (1, 10) | 4 (1, 8) | 4 (2, 8) | ||
| post_p | 0.1 (0.01, 0.36) | 0.29 (0.12, 0.47) | 0.19 (0.05, 0.43) | 0.19 (0.06, 0.42) | 0.27 (0.12, 0.47) | 0.29 (0.1, 0.47) | 0.33 (0.18, 0.48) | 0.31 (0.15, 0.46) | 0.28 (0.11, 0.44) | 0.29 (0.16, 0.43) | 0.29 (0.16, 0.45) | 0.32 (0.15, 0.45) | 0.32 (0.17, 0.46) | 0.32 (0.12, 0.47) | 0.29 (0.17, 0.45) | 0.29 (0.15, 0.44) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.122 (0.095, 0.182) | 0.142 (0.086, 0.405) | 0.125 (0.087, 0.223) | 0.135 (0.093, 0.359) | 0.128 (0.084, 0.261) | 0.141 (0.091, 0.335) | 0.141 (0.09, 0.485) | 0.153 (0.101, 0.487) | 0.137 (0.082, 0.408) | 0.165 (0.09, 0.511) | 0.147 (0.09, 0.456) | 0.123 (0.088, 0.394) | 0.143 (0.084, 0.453) | 0.144 (0.086, 0.357) | 0.156 (0.08, 0.479) | 0.157 (0.09, 0.416) | ||
| Hormone_therapies | count | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
| time | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | 26 (4, 35) | ||
| n | 20 (13, 44) | 4 (1, 8) | 10 (5, 32) | 6 (2, 26) | 2 (0, 7) | 2 (0, 9) | 2 (0, 8) | 2 (0, 7) | 4 (0, 12) | 3 (1, 10) | 3 (0, 10) | 3 (0, 9) | 2 (0, 7) | 2 (0, 7) | 2 (0, 7) | 2 (0, 7) | ||
| post_p | 0.13 (0.01, 0.41) | 0.3 (0.13, 0.45) | 0.19 (0.04, 0.43) | 0.28 (0.05, 0.46) | 0.31 (0.11, 0.42) | 0.35 (0.12, 0.46) | 0.33 (0.16, 0.47) | 0.34 (0.19, 0.48) | 0.3 (0.12, 0.45) | 0.3 (0.18, 0.48) | 0.3 (0.13, 0.47) | 0.28 (0.16, 0.46) | 0.34 (0.18, 0.45) | 0.32 (0.16, 0.49) | 0.33 (0.19, 0.44) | 0.35 (0.21, 0.47) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.115 (0.088, 0.16) | 0.161 (0.079, 0.455) | 0.129 (0.082, 0.248) | 0.127 (0.081, 0.396) | 0.154 (0.083, 0.556) | 0.16 (0.07, 0.384) | 0.132 (0.072, 0.436) | 0.165 (0.08, 0.537) | 0.133 (0.068, 0.411) | 0.156 (0.063, 0.607) | 0.152 (0.086, 0.548) | 0.155 (0.087, 0.451) | 0.153 (0.076, 0.606) | 0.149 (0.085, 0.693) | 0.158 (0.081, 0.522) | 0.146 (0.092, 0.516) | ||
| Niraparib | count | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | 79 | |
| time | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | 29 (21, 35) | ||
| n | 19 (8, 58) | 4 (1, 10) | 11 (4, 37) | 8 (3, 18) | 6 (2, 12) | 5 (3, 13) | 4 (1, 9) | 3 (1, 7) | 5 (2, 10) | 3 (1, 11) | 4 (1, 10) | 3 (2, 10) | 4 (1, 8) | 4 (1, 8) | 4 (1, 7) | 3 (2, 8) | ||
| post_p | 0.16 (0.02, 0.39) | 0.31 (0.12, 0.43) | 0.14 (0.03, 0.4) | 0.25 (0.08, 0.46) | 0.29 (0.12, 0.46) | 0.25 (0.08, 0.47) | 0.34 (0.17, 0.48) | 0.3 (0.16, 0.44) | 0.29 (0.11, 0.46) | 0.3 (0.12, 0.44) | 0.29 (0.13, 0.46) | 0.3 (0.17, 0.48) | 0.3 (0.17, 0.46) | 0.34 (0.16, 0.47) | 0.3 (0.13, 0.46) | 0.28 (0.14, 0.43) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.116 (0.089, 0.165) | 0.147 (0.096, 0.492) | 0.126 (0.091, 0.28) | 0.123 (0.086, 0.286) | 0.125 (0.091, 0.307) | 0.136 (0.087, 0.349) | 0.136 (0.076, 0.408) | 0.176 (0.093, 0.465) | 0.141 (0.084, 0.325) | 0.17 (0.081, 0.559) | 0.177 (0.088, 0.533) | 0.141 (0.089, 0.387) | 0.145 (0.086, 0.485) | 0.141 (0.088, 0.555) | 0.151 (0.089, 0.41) | 0.182 (0.096, 0.773) | ||
| DRD+ | Carboplatin | count | 183 | 183 | 183 | 183 | 183 | 183 | 183 | 183 | ||||||||
| time | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | ||||||||||
| n | 7 (3, 17) | 7 (2, 17) | 4 (2, 10) | 4 (1, 9) | 3 (1, 9) | 5 (1, 10) | 4 (1, 9) | 4 (1, 9) | ||||||||||
| post_p | 0.28 (0.09, 0.47) | 0.3 (0.11, 0.47) | 0.34 (0.16, 0.48) | 0.35 (0.16, 0.48) | 0.32 (0.14, 0.48) | 0.33 (0.14, 0.47) | 0.31 (0.17, 0.45) | 0.33 (0.15, 0.47) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.136 (0.088, 0.308) | 0.129 (0.088, 0.288) | 0.127 (0.078, 0.334) | 0.152 (0.088, 0.477) | 0.16 (0.083, 0.548) | 0.131 (0.085, 0.347) | 0.162 (0.081, 0.487) | 0.149 (0.082, 0.47) | ||||||||||
| Hormone_therapies | count | 111 | 111 | 111 | 111 | 111 | 111 | 111 | 111 | |||||||||
| time | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | 30 (23, 35) | ||||||||||
| n | 4 (1, 14) | 4 (1, 11) | 5 (1, 9) | 4 (1, 9) | 4 (1, 10) | 4 (1, 9) | 4 (1, 9) | 4 (1, 8) | ||||||||||
| post_p | 0.27 (0.11, 0.41) | 0.28 (0.09, 0.45) | 0.33 (0.16, 0.47) | 0.34 (0.19, 0.46) | 0.34 (0.17, 0.47) | 0.34 (0.17, 0.47) | 0.34 (0.17, 0.47) | 0.32 (0.21, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.148 (0.1, 0.596) | 0.154 (0.084, 0.423) | 0.136 (0.086, 0.497) | 0.155 (0.084, 0.701) | 0.14 (0.079, 0.564) | 0.148 (0.081, 0.44) | 0.149 (0.082, 0.517) | 0.149 (0.09, 0.404) | ||||||||||
| Niraparib | count | 175 | 175 | 175 | 175 | 175 | 175 | 175 | 175 | |||||||||
| time | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | ||||||||||
| n | 7 (3, 13) | 6 (2, 13) | 4 (1, 9) | 4 (1, 8) | 4 (1, 9) | 4 (1, 9) | 4 (2, 9) | 3 (1, 8) | ||||||||||
| post_p | 0.3 (0.11, 0.46) | 0.3 (0.1, 0.47) | 0.34 (0.18, 0.47) | 0.34 (0.17, 0.47) | 0.32 (0.17, 0.48) | 0.34 (0.16, 0.48) | 0.33 (0.17, 0.47) | 0.3 (0.16, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.129 (0.087, 0.25) | 0.139 (0.088, 0.37) | 0.144 (0.082, 0.457) | 0.151 (0.082, 0.521) | 0.146 (0.087, 0.564) | 0.147 (0.082, 0.517) | 0.15 (0.079, 0.365) | 0.17 (0.091, 0.483) | ||||||||||
| TEfus+ | Carboplatin | count | 191 | 191 | 191 | 191 | 191 | 191 | 191 | 191 | ||||||||
| time | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | ||||||||||
| n | 5 (2, 13) | 9 (3, 22) | 7 (3, 17) | 4 (2, 9) | 4 (2, 10) | 4 (1, 10) | 4 (1, 9) | 4 (1, 9) | ||||||||||
| post_p | 0.31 (0.11, 0.48) | 0.23 (0.06, 0.46) | 0.32 (0.1, 0.47) | 0.34 (0.17, 0.47) | 0.33 (0.15, 0.47) | 0.32 (0.17, 0.45) | 0.32 (0.14, 0.46) | 0.31 (0.16, 0.44) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.136 (0.078, 0.345) | 0.127 (0.087, 0.26) | 0.128 (0.08, 0.331) | 0.146 (0.091, 0.477) | 0.138 (0.08, 0.524) | 0.133 (0.083, 0.454) | 0.143 (0.086, 0.4) | 0.15 (0.088, 0.505) | ||||||||||
| Hormone_therapies | count | 198 | 198 | 198 | 198 | 198 | 198 | 198 | 198 | |||||||||
| time | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | ||||||||||
| n | 5 (3, 13) | 11 (4, 25) | 3 (1, 12) | 3 (0, 8) | 4 (2, 11) | 4 (2, 10) | 3 (1, 8) | 3 (1, 8) | ||||||||||
| post_p | 0.28 (0.1, 0.46) | 0.27 (0.06, 0.46) | 0.34 (0.16, 0.45) | 0.36 (0.19, 0.48) | 0.3 (0.13, 0.46) | 0.28 (0.14, 0.47) | 0.36 (0.19, 0.47) | 0.35 (0.2, 0.47) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.138 (0.086, 0.302) | 0.117 (0.079, 0.226) | 0.15 (0.089, 0.419) | 0.148 (0.079, 0.562) | 0.145 (0.082, 0.372) | 0.132 (0.087, 0.45) | 0.141 (0.082, 0.415) | 0.15 (0.081, 0.43) | ||||||||||
| Niraparib | count | 209 | 209 | 209 | 209 | 209 | 209 | 209 | 209 | |||||||||
| time | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | 23 (15, 35) | ||||||||||
| n | 4 (1, 11) | 8 (3, 20) | 6 (2, 14) | 4 (1, 9) | 4 (1, 10) | 3 (1, 10) | 4 (1, 9) | 4 (2, 8) | ||||||||||
| post_p | 0.31 (0.14, 0.47) | 0.26 (0.1, 0.48) | 0.3 (0.1, 0.47) | 0.34 (0.17, 0.47) | 0.31 (0.14, 0.46) | 0.32 (0.16, 0.48) | 0.33 (0.15, 0.48) | 0.3 (0.14, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.143 (0.086, 0.519) | 0.127 (0.079, 0.271) | 0.136 (0.08, 0.349) | 0.15 (0.086, 0.434) | 0.145 (0.076, 0.565) | 0.149 (0.084, 0.38) | 0.148 (0.082, 0.455) | 0.163 (0.091, 0.473) | ||||||||||
| TP53- & AR- | Carboplatin | count | 390 | 390 | 390 | 390 | ||||||||||||
| time | 21 (14, 31) | 21 (14, 31) | 21 (14, 31) | 21 (14, 31) | ||||||||||||||
| n | 20 (8, 60) | 5 (2, 12) | 7 (3, 16) | 7 (3, 17) | ||||||||||||||
| post_p | 0.19 (0.03, 0.45) | 0.35 (0.15, 0.48) | 0.32 (0.14, 0.47) | 0.34 (0.12, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.112 (0.084, 0.182) | 0.131 (0.077, 0.333) | 0.128 (0.085, 0.289) | 0.127 (0.085, 0.334) | ||||||||||||||
| Hormone_therapies | count | 409 | 409 | 409 | 409 | |||||||||||||
| time | 17 (9, 30) | 17 (9, 30) | 17 (9, 30) | 17 (9, 30) | ||||||||||||||
| n | 23 (16, 56) | 6 (3, 14) | 4 (1, 12) | 4 (1, 12) | ||||||||||||||
| post_p | 0.17 (0.02, 0.39) | 0.33 (0.12, 0.47) | 0.36 (0.18, 0.48) | 0.37 (0.19, 0.48) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.116 (0.089, 0.159) | 0.13 (0.081, 0.289) | 0.134 (0.071, 0.554) | 0.134 (0.074, 0.428) | ||||||||||||||
| Niraparib | count | 403 | 403 | 403 | 403 | |||||||||||||
| time | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | ||||||||||||||
| n | 19 (8, 58) | 5 (2, 14) | 7 (3, 15) | 6 (2, 15) | ||||||||||||||
| post_p | 0.19 (0.03, 0.44) | 0.36 (0.17, 0.47) | 0.35 (0.15, 0.48) | 0.32 (0.11, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.115 (0.086, 0.171) | 0.131 (0.079, 0.412) | 0.119 (0.078, 0.283) | 0.133 (0.085, 0.358) | ||||||||||||||
| TP53+ | Carboplatin | count | 223 | 223 | 223 | 223 | 223 | 223 | 223 | 223 | ||||||||
| time | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | ||||||||||
| n | 11 (5, 36) | 9 (3, 25) | 4 (2, 10) | 4 (2, 9) | 4 (1, 10) | 4 (1, 11) | 4 (1, 8) | 4 (1, 8) | ||||||||||
| post_p | 0.21 (0.04, 0.46) | 0.27 (0.11, 0.46) | 0.34 (0.17, 0.48) | 0.35 (0.18, 0.48) | 0.31 (0.13, 0.46) | 0.35 (0.18, 0.47) | 0.32 (0.18, 0.47) | 0.32 (0.17, 0.45) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.122 (0.086, 0.248) | 0.119 (0.087, 0.243) | 0.138 (0.076, 0.403) | 0.149 (0.086, 0.477) | 0.149 (0.083, 0.53) | 0.13 (0.08, 0.494) | 0.158 (0.083, 0.535) | 0.15 (0.088, 0.506) | ||||||||||
| Hormone_therapies | count | 229 | 229 | 229 | 229 | 229 | 229 | 229 | 229 | |||||||||
| time | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | 24 (13, 34) | ||||||||||
| n | 14 (7, 44) | 9 (4, 28) | 3 (1, 9) | 3 (0, 8) | 4 (2, 12) | 4 (2, 11) | 3 (1, 8) | 3 (1, 9) | ||||||||||
| post_p | 0.18 (0.03, 0.43) | 0.24 (0.07, 0.45) | 0.35 (0.18, 0.48) | 0.35 (0.17, 0.48) | 0.33 (0.14, 0.47) | 0.31 (0.15, 0.47) | 0.34 (0.19, 0.47) | 0.36 (0.17, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.117 (0.088, 0.197) | 0.122 (0.084, 0.251) | 0.137 (0.074, 0.617) | 0.154 (0.083, 0.607) | 0.144 (0.084, 0.418) | 0.13 (0.076, 0.48) | 0.16 (0.078, 0.54) | 0.145 (0.084, 0.44) | ||||||||||
| Niraparib | count | 231 | 231 | 231 | 231 | 231 | 231 | 231 | 231 | |||||||||
| time | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | 24 (15, 33) | ||||||||||
| n | 12 (4, 37) | 8 (3, 19) | 4 (1, 9) | 4 (1, 8) | 4 (1, 10) | 3 (1, 10) | 4 (2, 8) | 3 (1, 9) | ||||||||||
| post_p | 0.19 (0.06, 0.44) | 0.25 (0.08, 0.46) | 0.35 (0.17, 0.48) | 0.33 (0.17, 0.47) | 0.34 (0.14, 0.48) | 0.33 (0.16, 0.47) | 0.34 (0.15, 0.48) | 0.31 (0.14, 0.47) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.121 (0.09, 0.25) | 0.131 (0.086, 0.281) | 0.136 (0.077, 0.384) | 0.157 (0.082, 0.43) | 0.145 (0.084, 0.437) | 0.14 (0.081, 0.385) | 0.145 (0.078, 0.334) | 0.174 (0.093, 0.455) |