Simulation scenario 3

Setting description

Taxel_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 3 264 0 1 TP53- & AR- 1 375 2 1 TP53+ 1 278 1 0 DRD+ 1 100 0 0 TEfus+ 0 260 1 1

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.006 0.528 0.000 0.002 TP53- & AR- 0.002 0.750 0.004 0.002 TP53+ 0.002 0.556 0.002 0.000 DRD+ 0.002 0.200 0.000 0.000 TEfus+ 0.000 0.520 0.002 0.002

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 100 0 74 79 TP53- & AR- 409 0 390 403 TP53+ 229 0 223 231 DRD+ 111 0 183 175 TEfus+ 198 0 191 209

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.200 0 0.148 0.158 TP53- & AR- 0.818 0 0.780 0.806 TP53+ 0.458 0 0.446 0.462 DRD+ 0.222 0 0.366 0.350 TEfus+ 0.396 0 0.382 0.418

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 5 14 30 17 TP53+ 19 77 24 22 DRD+ 0 0 0 0 TEfus+ 1 1 2 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.010 0.028 0.060 0.034 TP53+ 0.038 0.154 0.048 0.044 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.002 0.004 0.004

Errors & power

The overall error was 0.456.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.012             0.440             0.008             0.006 

The overall power was 0.528.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.528             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	0	0	3	1	264
	futility	74	0	100	79	0
	max_n	0	0	0	0	0
	n	155 (94, 249)	432 (352, 477)	139 (80, 225)	154 (89, 244)	142 (49, 278)
	n_unique	144 (87, 239)	401 (329, 445)	130 (74, 211)	144 (82, 231)	132 (45, 259)
	time_trial	36 (33, 36)	36 (36, 36)	36 (25, 36)	36 (31, 36)	32 (8, 36)
	time_stop	30 (20, 36)	NA (NA, NA)	25 (4, 35)	29 (20, 35)	14 (6, 28)
	post_p	0 (0, 0.01)	NA (NA, NA)	0 (0, 0.01)	0 (0, 0.01)	1 (1, 1)
	rate	0.113 (0.101, 0.129)	0.075 (0.069, 0.081)	0.114 (0.101, 0.131)	0.113 (0.102, 0.13)	0.036 (0.031, 0.041)
DRD+	graduation	0	0	1	0	100
	futility	183	0	111	175	0
	max_n	0	0	0	0	0
	n	55 (33, 80)	112 (90, 133)	41 (19, 69)	53 (29, 83)	26 (5, 59)
	n_unique	51 (30, 76)	105 (83, 123)	38 (17, 63)	49 (27, 78)	24 (5, 56)
	time_trial	36 (22, 36)	36 (36, 36)	36 (29, 36)	36 (20, 36)	36 (24, 36)
	time_stop	26 (17, 34)	NA (NA, NA)	30 (23, 35)	24 (16, 34)	24 (16, 33)
	post_p	0.02 (0, 0.15)	NA (NA, NA)	0.04 (0, 0.26)	0.02 (0, 0.16)	1 (0.87, 1)
	rate	0.116 (0.096, 0.141)	0.075 (0.064, 0.086)	0.114 (0.093, 0.156)	0.114 (0.096, 0.145)	0.036 (0.023, 0.051)
TEfus+	graduation	1	0	0	1	260
	futility	191	0	198	209	0
	max_n	2	0	1	2	1
	n	62 (33, 101)	155 (127, 178)	54 (25, 91)	59 (30, 105)	43 (20, 103)
	n_unique	57 (31, 95)	144 (118, 167)	50 (23, 85)	54 (27, 96)	39 (18, 97)
	time_trial	36 (20, 36)	36 (36, 36)	36 (21, 36)	36 (18, 36)	33 (11, 36)
	time_stop	25 (17, 34)	NA (NA, NA)	26 (17, 34)	23 (15, 35)	15 (10, 29)
	post_p	0.02 (0, 0.15)	NA (NA, NA)	0.02 (0, 0.16)	0.01 (0, 0.13)	1 (0.99, 1)
	rate	0.113 (0.096, 0.138)	0.075 (0.066, 0.085)	0.115 (0.096, 0.144)	0.115 (0.097, 0.145)	0.037 (0.028, 0.045)
TP53- & AR-	graduation	2	0	1	1	375
	futility	390	0	409	403	0
	max_n	30	0	5	17	14
	n	47 (26, 136)	166 (99, 203)	39 (25, 105)	42 (25, 123)	31 (18, 116)
	n_unique	43 (24, 130)	155 (92, 191)	37 (23, 101)	40 (24, 118)	29 (15, 111)
	time_trial	23 (15, 36)	36 (36, 36)	19 (9, 36)	22 (13, 36)	15 (9, 36)
	time_stop	21 (14, 31)	NA (NA, NA)	17 (9, 30)	20 (13, 31)	12 (9, 24)
	post_p	0.02 (0, 0.13)	NA (NA, NA)	0.02 (0, 0.13)	0.02 (0, 0.14)	1 (0.98, 1)
	rate	0.114 (0.098, 0.145)	0.075 (0.066, 0.085)	0.117 (0.098, 0.151)	0.115 (0.098, 0.142)	0.036 (0.027, 0.046)
TP53+	graduation	1	0	1	0	278
	futility	223	0	229	231	0
	max_n	24	0	19	22	77
	n	71 (35, 127)	200 (173, 226)	66 (27, 120)	70 (32, 132)	59 (25, 152)
	n_unique	66 (32, 118)	188 (162, 210)	61 (26, 114)	65 (30, 123)	56 (22, 143)
	time_trial	36 (18, 36)	36 (36, 36)	36 (17, 36)	36 (17, 36)	30 (9, 36)
	time_stop	24 (13, 34)	NA (NA, NA)	24 (13, 34)	24 (15, 33)	14 (8, 29)
	post_p	0.01 (0, 0.09)	NA (NA, NA)	0.01 (0, 0.11)	0.01 (0, 0.09)	1 (0.99, 1)
	rate	0.114 (0.098, 0.137)	0.075 (0.067, 0.084)	0.114 (0.096, 0.142)	0.114 (0.099, 0.142)	0.036 (0.029, 0.044)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	396	0	442	412	464
	futility	0	0	0	0	0
	max_n	30	0	5	17	14
	n	24 (9, 86)	108 (63, 135)	23 (15, 67)	21 (8, 83)	22 (10, 83)
	n_unique	22 (8, 83)	101 (57, 127)	22 (14, 66)	20 (7, 79)	21 (10, 80)
	post_p	0.08 (0, 0.3)	NA (NA, NA)	0.06 (0, 0.26)	0.07 (0, 0.33)	1 (0.92, 1)
	rate	0.115 (0.093, 0.173)	0.075 (0.064, 0.087)	0.117 (0.093, 0.157)	0.115 (0.091, 0.173)	0.035 (0.026, 0.049)
—+	graduation	410	0	457	429	469
	futility	0	0	0	0	0
	max_n	31	0	5	19	14
	n	6 (2, 16)	18 (10, 27)	6 (2, 15)	5 (2, 17)	5 (2, 12)
	n_unique	5 (2, 16)	17 (9, 25)	5 (2, 14)	5 (1, 16)	5 (2, 11)
	post_p	0.28 (0.11, 0.62)	NA (NA, NA)	0.26 (0.09, 0.54)	0.28 (0.1, 0.58)	0.87 (0.53, 0.99)
	rate	0.126 (0.073, 0.283)	0.074 (0.05, 0.111)	0.134 (0.082, 0.304)	0.13 (0.076, 0.392)	0.037 (0.017, 0.079)
–+-	graduation	227	0	260	234	360
	futility	0	0	0	0	0
	max_n	24	0	19	22	73
	n	16 (5, 51)	69 (57, 83)	16 (7, 51)	15 (5, 52)	22 (6, 63)
	n_unique	15 (5, 49)	66 (54, 78)	15 (6, 49)	14 (5, 49)	21 (5, 61)
	post_p	0.12 (0.03, 0.44)	NA (NA, NA)	0.12 (0.02, 0.36)	0.13 (0.02, 0.41)	1 (0.83, 1)
	rate	0.121 (0.088, 0.211)	0.076 (0.062, 0.092)	0.12 (0.091, 0.196)	0.12 (0.089, 0.23)	0.036 (0.023, 0.054)
–++	graduation	292	0	331	297	415
	futility	0	0	0	0	0
	max_n	25	0	19	23	71
	n	11 (4, 33)	46 (33, 56)	12 (4, 33)	10 (4, 34)	14 (6, 40)
	n_unique	10 (3, 32)	43 (31, 54)	11 (3, 31)	9 (3, 32)	13 (5, 37)
	post_p	0.2 (0.04, 0.51)	NA (NA, NA)	0.19 (0.05, 0.47)	0.18 (0.04, 0.46)	0.98 (0.76, 1)
	rate	0.121 (0.082, 0.22)	0.076 (0.06, 0.096)	0.119 (0.084, 0.239)	0.125 (0.086, 0.241)	0.038 (0.023, 0.058)
-+–	graduation	414	0	449	425	467
	futility	0	0	0	0	0
	max_n	30	0	5	17	14
	n	8 (3, 20)	19 (10, 27)	4 (0, 14)	8 (3, 19)	3 (0, 11)
	n_unique	7 (3, 19)	17 (8, 26)	4 (0, 14)	7 (2, 18)	2 (0, 10)
	post_p	0.27 (0.09, 0.54)	NA (NA, NA)	0.3 (0.12, 0.57)	0.26 (0.09, 0.54)	0.8 (0.48, 0.97)
	rate	0.124 (0.079, 0.265)	0.074 (0.051, 0.107)	0.137 (0.077, 0.494)	0.121 (0.08, 0.244)	0.039 (0.008, 0.091)
-+-+	graduation	423	0	465	438	472
	futility	0	0	0	0	0
	max_n	31	0	4	19	14
	n	8 (3, 20)	17 (9, 27)	4 (0, 13)	6 (2, 19)	3 (0, 9)
	n_unique	8 (3, 19)	16 (8, 25)	4 (0, 13)	6 (2, 17)	2 (0, 8)
	post_p	0.29 (0.1, 0.61)	NA (NA, NA)	0.31 (0.14, 0.59)	0.27 (0.09, 0.59)	0.82 (0.48, 0.98)
	rate	0.12 (0.078, 0.29)	0.078 (0.051, 0.113)	0.136 (0.079, 0.411)	0.128 (0.082, 0.347)	0.039 (0, 0.101)
-++-	graduation	281	0	286	280	381
	futility	0	0	0	0	0
	max_n	22	0	19	22	71
	n	5 (2, 12)	13 (8, 18)	4 (1, 11)	5 (2, 12)	2 (0, 9)
	n_unique	5 (2, 12)	12 (7, 17)	4 (1, 10)	5 (1, 11)	2 (0, 9)
	post_p	0.31 (0.14, 0.62)	NA (NA, NA)	0.34 (0.16, 0.61)	0.32 (0.15, 0.6)	0.77 (0.4, 0.95)
	rate	0.127 (0.073, 0.316)	0.075 (0.048, 0.118)	0.127 (0.072, 0.395)	0.125 (0.07, 0.336)	0.041 (0, 0.14)
-+++	graduation	327	0	342	326	423
	futility	0	0	0	0	0
	max_n	23	0	19	23	69
	n	5 (2, 13)	12 (7, 17)	4 (0, 10)	5 (1, 13)	2 (0, 7)
	n_unique	5 (1, 12)	11 (6, 16)	3 (0, 10)	5 (1, 12)	2 (0, 7)
	post_p	0.32 (0.14, 0.59)	NA (NA, NA)	0.35 (0.16, 0.65)	0.32 (0.15, 0.66)	0.77 (0.41, 0.95)
	rate	0.134 (0.079, 0.39)	0.078 (0.046, 0.125)	0.132 (0.072, 0.494)	0.134 (0.073, 0.348)	0.041 (0, 0.119)
+—	graduation	74	0	103	80	264
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 15)	22 (15, 28)	5 (2, 16)	6 (2, 15)	13 (3, 26)
	n_unique	5 (2, 15)	20 (14, 27)	5 (2, 14)	5 (2, 14)	12 (3, 24)
	post_p	0.28 (0.1, 0.58)	NA (NA, NA)	0.26 (0.11, 0.57)	0.28 (0.11, 0.54)	0.94 (0.64, 1)
	rate	0.128 (0.073, 0.373)	0.076 (0.053, 0.106)	0.129 (0.075, 0.363)	0.128 (0.073, 0.313)	0.035 (0.02, 0.065)
+–+	graduation	196	0	239	215	366
	futility	0	0	0	0	0
	max_n	2	0	1	2	1
	n	5 (2, 14)	18 (12, 24)	5 (2, 14)	5 (2, 14)	7 (2, 18)
	n_unique	5 (2, 13)	16 (11, 23)	5 (1, 13)	5 (2, 13)	6 (2, 17)
	post_p	0.3 (0.12, 0.58)	NA (NA, NA)	0.29 (0.11, 0.59)	0.3 (0.12, 0.56)	0.88 (0.55, 0.98)
	rate	0.126 (0.071, 0.333)	0.075 (0.048, 0.117)	0.133 (0.07, 0.388)	0.129 (0.068, 0.389)	0.038 (0.018, 0.075)
+-+-	graduation	227	0	260	234	360
	futility	0	0	0	0	0
	max_n	24	0	19	22	73
	n	5 (2, 14)	18 (11, 24)	5 (1, 14)	6 (2, 15)	6 (2, 18)
	n_unique	5 (1, 13)	16 (11, 23)	5 (1, 13)	5 (2, 14)	6 (2, 17)
	post_p	0.31 (0.12, 0.56)	NA (NA, NA)	0.29 (0.13, 0.59)	0.29 (0.12, 0.6)	0.88 (0.52, 0.99)
	rate	0.126 (0.074, 0.424)	0.074 (0.051, 0.114)	0.132 (0.068, 0.385)	0.127 (0.068, 0.348)	0.038 (0.017, 0.088)
+-++	graduation	292	0	331	297	415
	futility	0	0	0	0	0
	max_n	25	0	19	23	71
	n	6 (2, 15)	17 (12, 23)	5 (2, 14)	5 (2, 13)	5 (2, 15)
	n_unique	5 (1, 14)	16 (10, 22)	4 (1, 12)	5 (2, 13)	5 (1, 15)
	post_p	0.31 (0.13, 0.62)	NA (NA, NA)	0.3 (0.12, 0.57)	0.3 (0.12, 0.59)	0.88 (0.55, 0.98)
	rate	0.122 (0.073, 0.355)	0.075 (0.048, 0.111)	0.125 (0.073, 0.39)	0.129 (0.073, 0.344)	0.036 (0.016, 0.074)
++–	graduation	187	0	167	182	303
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	5 (2, 12)	13 (8, 18)	4 (1, 11)	5 (2, 11)	4 (0, 12)
	n_unique	4 (2, 11)	12 (7, 17)	4 (1, 10)	4 (2, 10)	4 (0, 11)
	post_p	0.32 (0.14, 0.6)	NA (NA, NA)	0.35 (0.16, 0.64)	0.32 (0.14, 0.59)	0.8 (0.45, 0.97)
	rate	0.13 (0.076, 0.382)	0.075 (0.044, 0.12)	0.126 (0.064, 0.421)	0.128 (0.071, 0.415)	0.038 (0.003, 0.107)
++-+	graduation	260	0	276	272	389
	futility	0	0	0	0	0
	max_n	2	0	0	2	1
	n	5 (2, 11)	12 (7, 19)	4 (1, 11)	5 (2, 13)	2 (0, 10)
	n_unique	5 (1, 11)	12 (7, 17)	4 (1, 10)	5 (1, 12)	2 (0, 9)
	post_p	0.32 (0.14, 0.61)	NA (NA, NA)	0.34 (0.16, 0.65)	0.33 (0.13, 0.63)	0.81 (0.43, 0.97)
	rate	0.128 (0.076, 0.411)	0.077 (0.046, 0.13)	0.132 (0.068, 0.359)	0.129 (0.072, 0.377)	0.039 (0, 0.127)
+++-	graduation	281	0	286	280	381
	futility	0	0	0	0	0
	max_n	22	0	19	22	71
	n	5 (1, 12)	13 (8, 18)	4 (1, 11)	5 (2, 12)	2 (0, 9)
	n_unique	5 (1, 12)	11 (7, 17)	4 (1, 10)	5 (2, 11)	2 (0, 9)
	post_p	0.31 (0.13, 0.59)	NA (NA, NA)	0.34 (0.15, 0.63)	0.33 (0.15, 0.6)	0.8 (0.45, 0.96)
	rate	0.133 (0.076, 0.396)	0.076 (0.048, 0.126)	0.13 (0.068, 0.421)	0.127 (0.075, 0.302)	0.035 (0, 0.114)
++++	graduation	327	0	342	326	423
	futility	0	0	0	0	0
	max_n	23	0	19	23	69
	n	5 (2, 13)	12 (7, 17)	4 (1, 11)	5 (2, 12)	2 (0, 7)
	n_unique	5 (1, 12)	11 (7, 16)	4 (0, 10)	5 (1, 11)	2 (0, 7)
	post_p	0.32 (0.14, 0.62)	NA (NA, NA)	0.35 (0.16, 0.66)	0.31 (0.14, 0.62)	0.78 (0.42, 0.96)
	rate	0.13 (0.072, 0.407)	0.076 (0.046, 0.125)	0.135 (0.068, 0.371)	0.136 (0.073, 0.362)	0.04 (0, 0.138)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Niraparib	Carboplatin
all	count	3	264	1
	time_stop	3 (3, 5)	14 (6, 28)	7 (7, 7)
	n_trt	27 (27, 34)	86 (37, 202)	31 (31, 31)
	n_control	34 (34, 56)	146 (65, 327)	75 (75, 75)
	post_p	0.94 (0.9, 0.95)	1 (0.98, 1)	0.88 (0.88, 0.88)
	order	1 (1, 1)	2 (1, 3)	1 (1, 1)
TP53- & AR-	count	1	375	1	2
	time_stop	13 (13, 13)	12 (9, 24)	15 (15, 15)	12 (12, 13)
	n_trt	32 (32, 32)	33 (25, 83)	26 (26, 26)	30 (26, 33)
	n_control	64 (64, 64)	53 (35, 118)	74 (74, 74)	60 (58, 62)
	post_p	0.88 (0.88, 0.88)	0.98 (0.91, 1)	0.97 (0.97, 0.97)	0.93 (0.92, 0.94)
	order	3 (3, 3)	1 (1, 3)	4 (4, 4)	4 (4, 4)
TP53+	count	1	278		1
	time_stop	7 (7, 7)	14 (8, 29)		10 (10, 10)
	n_trt	26 (26, 26)	44 (27, 113)		27 (27, 27)
	n_control	26 (26, 26)	64 (36, 156)		51 (51, 51)
	post_p	0.93 (0.93, 0.93)	1 (0.95, 1)		0.92 (0.92, 0.92)
	order	1 (1, 1)	2 (1, 4)		1 (1, 1)
DRD+	count	1	100
	time_stop	15 (15, 15)	24 (16, 33)
	n_trt	26 (26, 26)	30 (25, 55)
	n_control	41 (41, 41)	66 (41, 101)
	post_p	0.86 (0.86, 0.86)	1 (0.98, 1)
	order	5 (5, 5)	3 (1, 5)
TEfus+	count		260	1	1
	time_stop		15 (10, 29)	12 (12, 12)	10 (10, 10)
	n_trt		38 (26, 77)	25 (25, 25)	26 (26, 26)
	n_control		60 (35, 126)	49 (49, 49)	42 (42, 42)
	post_p		1 (0.97, 1)	0.95 (0.95, 0.95)	0.91 (0.91, 0.91)
	order		2 (1, 4)	2 (2, 2)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Carboplatin	Niraparib
all	count	100	74	79
	time_stop	26 (4, 35)	30 (20, 36)	29 (21, 35)
	n_trt	88 (28, 167)	116 (80, 197)	106 (72, 173)
	n_control	281 (38, 419)	333 (225, 429)	321 (223, 410)
	post_p	0 (0, 0.11)	0 (0, 0.01)	0 (0, 0)
	order	5.5 (1, 9)	6 (3.3, 9)	6 (3, 9)
TP53- & AR-	count	409	390	403
	time_stop	17 (9, 30)	21 (14, 31)	20 (13, 31)
	n_trt	37 (25, 87)	40 (25, 93)	37 (25, 93)
	n_control	75 (36, 149)	102 (60, 162)	96 (55, 162)
	post_p	0.07 (0, 0.23)	0.06 (0, 0.19)	0.06 (0, 0.2)
	order	2 (1, 5)	3 (1, 6)	3 (1, 6)
TP53+	count	229	223	231
	time_stop	24 (13, 34)	24 (14, 34)	24 (15, 33)
	n_trt	49 (28, 109)	49 (28, 95)	49 (27, 89)
	n_control	129 (58, 194)	130 (63, 190)	123 (66, 185)
	post_p	0.01 (0, 0.09)	0.01 (0, 0.08)	0.01 (0, 0.07)
	order	4 (1, 8)	4 (1, 7)	4 (1, 8)
DRD+	count	111	183	175
	time_stop	30 (23, 35)	26 (17, 34)	24 (16, 34)
	n_trt	37 (26, 58)	43 (29, 67)	39 (27, 57)
	n_control	93 (67, 123)	82 (49, 111)	73 (43, 110)
	post_p	0.01 (0, 0.06)	0.01 (0, 0.07)	0.01 (0, 0.08)
	order	6 (3, 9)	5 (2, 8)	4 (2, 9)
TEfus+	count	198	191	209
	time_stop	26 (17, 34)	25 (17, 34)	23 (15, 35)
	n_trt	44 (26, 74)	47 (29, 75)	41 (26, 70)
	n_control	108 (64, 153)	107 (69, 149)	98 (59, 152)
	post_p	0.02 (0, 0.08)	0.01 (0, 0.07)	0.01 (0, 0.06)
	order	5 (2, 9)	5 (2, 9)	5 (2, 8)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)	3 (3, 5)
		n	14 (12, 16)	2 (2, 2)	8 (7, 9)	2 (1, 3)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	0 (0, 2)	0 (0, 1)	0 (0, 2)	0 (0, 0)	0 (0, 0)	0 (0, 2)	0 (0, 0)
		post_p	0.63 (0.58, 0.73)	0.54 (0.52, 0.56)	0.63 (0.55, 0.7)	0.6 (0.58, 0.61)	0.58 (0.58, 0.58)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)	0.61 (0.61, 0.61)	0.64 (0.64, 0.64)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.076 (0.05, 0.083)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
		n	7 (7, 7)	1 (1, 1)	5 (5, 5)	1 (1, 1)	2 (2, 2)	2 (2, 2)	2 (2, 2)	0 (0, 0)	0 (0, 0)	1 (1, 1)	5 (5, 5)	0 (0, 0)	3 (3, 3)	1 (1, 1)	0 (0, 0)	1 (1, 1)
		post_p	0.5 (0.5, 0.5)	0.51 (0.51, 0.51)	0.55 (0.55, 0.55)	0.54 (0.54, 0.54)	0.64 (0.64, 0.64)	0.69 (0.69, 0.69)	0.61 (0.61, 0.61)	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)	NA (NA, NA)	0.62 (0.62, 0.62)	0.57 (0.57, 0.57)	NA (NA, NA)	0.58 (0.58, 0.58)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.074 (0.074, 0.074)	0 (0, 0)	0.059 (0.059, 0.059)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0.081 (0.081, 0.081)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
	Taxel_therapies	count	264	264	264	264	264	264	264	264	264	264	264	264	264	264	264	264
		time	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)	14 (6, 28)
		n	19 (7, 46)	4 (2, 10)	13 (4, 41)	12 (5, 27)	2 (0, 7)	2 (0, 6)	2 (0, 6)	1 (0, 5)	7 (2, 16)	5 (2, 12)	4 (1, 10)	4 (1, 10)	2 (0, 6)	1 (0, 6)	1 (0, 6)	1 (0, 5)
		post_p	0.92 (0.62, 1)	0.74 (0.55, 0.95)	0.85 (0.58, 1)	0.8 (0.57, 0.98)	0.66 (0.52, 0.89)	0.68 (0.53, 0.88)	0.66 (0.54, 0.86)	0.63 (0.52, 0.85)	0.75 (0.54, 0.97)	0.68 (0.53, 0.93)	0.67 (0.53, 0.89)	0.69 (0.53, 0.92)	0.64 (0.52, 0.87)	0.64 (0.52, 0.89)	0.63 (0.51, 0.9)	0.66 (0.52, 0.88)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.033 (0, 0.058)	0.022 (0, 0.072)	0.032 (0, 0.063)	0.035 (0, 0.065)	0 (0, 0.068)	0 (0, 0.075)	0 (0, 0.064)	0 (0, 0.084)	0.028 (0, 0.062)	0.022 (0, 0.069)	0.029 (0, 0.074)	0.023 (0, 0.08)	0 (0, 0.076)	0 (0, 0.071)	0 (0, 0.074)	0 (0, 0.061)
DRD+	Hormone_therapies	count					1	1	1	1					1	1	1	1
		time					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)
		n					9 (9, 9)	0 (0, 0)	1 (1, 1)	3 (3, 3)					2 (2, 2)	3 (3, 3)	2 (2, 2)	6 (6, 6)
		post_p					0.71 (0.71, 0.71)	NA (NA, NA)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)					0.52 (0.52, 0.52)	0.71 (0.71, 0.71)	0.56 (0.56, 0.56)	0.72 (0.72, 0.72)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.055 (0.055, 0.055)	NA (NA, NA)	0 (0, 0)	0 (0, 0)					0.092 (0.092, 0.092)	0.065 (0.065, 0.065)	0.083 (0.083, 0.083)	0.084 (0.084, 0.084)
	Taxel_therapies	count					100	100	100	100					100	100	100	100
		time					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)					24 (16, 33)	24 (16, 33)	24 (16, 33)	24 (16, 33)
		n					4 (1, 11)	4 (1, 11)	4 (1, 9)	2 (0, 7)					4 (1, 10)	3 (1, 8)	3 (0, 9)	3 (0, 7)
		post_p					0.77 (0.6, 0.94)	0.77 (0.58, 0.94)	0.74 (0.53, 0.93)	0.73 (0.53, 0.89)					0.73 (0.52, 0.93)	0.75 (0.55, 0.95)	0.75 (0.53, 0.92)	0.72 (0.54, 0.9)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.034 (0, 0.069)	0.034 (0, 0.075)	0.026 (0, 0.09)	0.032 (0, 0.089)					0.02 (0, 0.076)	0.019 (0, 0.061)	0.016 (0, 0.083)	0.03 (0, 0.078)
TEfus+	Carboplatin	count		1		1		1		1		1		1		1		1
		time		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)		10 (10, 10)
		n		3 (3, 3)		3 (3, 3)		5 (5, 5)		1 (1, 1)		3 (3, 3)		3 (3, 3)		4 (4, 4)		4 (4, 4)
		post_p		0.66 (0.66, 0.66)		0.62 (0.62, 0.62)		0.69 (0.69, 0.69)		0.68 (0.68, 0.68)		0.61 (0.61, 0.61)		0.52 (0.52, 0.52)		0.72 (0.72, 0.72)		0.7 (0.7, 0.7)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0.116 (0.116, 0.116)		0 (0, 0)		0 (0, 0)		0.086 (0.086, 0.086)		0.075 (0.075, 0.075)		0 (0, 0)
	Niraparib	count		1		1		1		1		1		1		1		1
		time		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)
		n		2 (2, 2)		4 (4, 4)		5 (5, 5)		2 (2, 2)		0 (0, 0)		4 (4, 4)		4 (4, 4)		4 (4, 4)
		post_p		0.54 (0.54, 0.54)		0.67 (0.67, 0.67)		0.66 (0.66, 0.66)		0.54 (0.54, 0.54)		NA (NA, NA)		0.63 (0.63, 0.63)		0.71 (0.71, 0.71)		0.58 (0.58, 0.58)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0.042 (0.042, 0.042)		0 (0, 0)		NA (NA, NA)		0 (0, 0)		0.046 (0.046, 0.046)		0.038 (0.038, 0.038)
	Taxel_therapies	count		260		260		260		260		260		260		260		260
		time		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)		15 (10, 29)
		n		5 (2, 11)		14 (8, 28)		2 (0, 6)		2 (0, 5)		5 (2, 12)		5 (2, 11)		2 (0, 7)		2 (0, 5)
		post_p		0.77 (0.57, 0.95)		0.86 (0.73, 1)		0.7 (0.53, 0.89)		0.66 (0.52, 0.88)		0.74 (0.54, 0.93)		0.77 (0.55, 0.93)		0.67 (0.52, 0.92)		0.66 (0.53, 0.87)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.027 (0, 0.064)		0.035 (0.014, 0.063)		0 (0, 0.079)		0 (0, 0.08)		0.031 (0, 0.069)		0.028 (0, 0.071)		0 (0, 0.069)		0 (0, 0.076)
TP53- & AR-	Carboplatin	count	2	2			2	2
		time	12 (12, 13)	12 (12, 13)			12 (12, 13)	12 (12, 13)
		n	14 (9, 19)	2 (2, 3)			4 (3, 5)	9 (7, 11)
		post_p	0.79 (0.76, 0.81)	0.56 (0.54, 0.59)			0.57 (0.52, 0.61)	0.79 (0.74, 0.85)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.022 (0.004, 0.04)	0 (0, 0)			0.082 (0.056, 0.109)	0.039 (0.037, 0.041)
	Hormone_therapies	count	1	1			1	1
		time	13 (13, 13)	13 (13, 13)			13 (13, 13)	13 (13, 13)
		n	23 (23, 23)	5 (5, 5)			4 (4, 4)	0 (0, 0)
		post_p	0.83 (0.83, 0.83)	0.54 (0.54, 0.54)			0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.074 (0.074, 0.074)	0.059 (0.059, 0.059)			0.071 (0.071, 0.071)	NA (NA, NA)
	Niraparib	count	1	1			1	1
		time	15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
		n	16 (16, 16)	1 (1, 1)			5 (5, 5)	4 (4, 4)
		post_p	0.78 (0.78, 0.78)	0.54 (0.54, 0.54)			0.84 (0.84, 0.84)	0.53 (0.53, 0.53)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.053 (0.053, 0.053)	0 (0, 0)			0 (0, 0)	0.072 (0.072, 0.072)
	Taxel_therapies	count	375	375			375	375
		time	12 (9, 24)	12 (9, 24)			12 (9, 24)	12 (9, 24)
		n	23 (16, 59)	5 (2, 11)			3 (1, 9)	3 (0, 8)
		post_p	0.92 (0.76, 1)	0.74 (0.55, 0.91)			0.64 (0.52, 0.86)	0.64 (0.52, 0.89)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.032 (0.014, 0.051)	0.026 (0, 0.071)			0 (0, 0.074)	0 (0, 0.08)
TP53+	Carboplatin	count			1	1			1	1			1	1			1	1
		time			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)			10 (10, 10)	10 (10, 10)
		n			7 (7, 7)	4 (4, 4)			0 (0, 0)	3 (3, 3)			4 (4, 4)	2 (2, 2)			3 (3, 3)	4 (4, 4)
		post_p			0.77 (0.77, 0.77)	0.76 (0.76, 0.76)			NA (NA, NA)	0.56 (0.56, 0.56)			0.57 (0.57, 0.57)	0.57 (0.57, 0.57)			0.61 (0.61, 0.61)	0.7 (0.7, 0.7)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.062 (0.062, 0.062)	0 (0, 0)			NA (NA, NA)	0.095 (0.095, 0.095)			0.047 (0.047, 0.047)	0 (0, 0)			0 (0, 0)	0.101 (0.101, 0.101)
	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)			7 (7, 7)	7 (7, 7)
		n			16 (16, 16)	4 (4, 4)			1 (1, 1)	0 (0, 0)			2 (2, 2)	3 (3, 3)			0 (0, 0)	0 (0, 0)
		post_p			0.84 (0.84, 0.84)	0.6 (0.6, 0.6)			0.58 (0.58, 0.58)	NA (NA, NA)			0.63 (0.63, 0.63)	0.53 (0.53, 0.53)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.031 (0.031, 0.031)	0.064 (0.064, 0.064)			0 (0, 0)	NA (NA, NA)			0 (0, 0)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count			278	278			278	278			278	278			278	278
		time			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)			14 (8, 29)	14 (8, 29)
		n			16 (7, 47)	13 (7, 27)			2 (0, 6)	1 (0, 5)			5 (2, 12)	4 (2, 12)			2 (0, 6)	2 (0, 6)
		post_p			0.89 (0.72, 1)	0.85 (0.71, 0.99)			0.64 (0.52, 0.87)	0.63 (0.52, 0.86)			0.73 (0.53, 0.92)	0.75 (0.54, 0.94)			0.63 (0.52, 0.92)	0.68 (0.52, 0.89)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.033 (0, 0.058)	0.036 (0.011, 0.062)			0 (0, 0.073)	0 (0, 0.071)			0.032 (0, 0.079)	0.024 (0, 0.072)			0 (0, 0.063)	0 (0, 0.072)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	74	74	74	74	74	74	74	74	74	74	74	74	74	74	74	74
		time	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)	30 (20, 36)
		n	21 (9, 63)	5 (2, 15)	12 (5, 39)	8 (3, 19)	7 (3, 17)	7 (2, 17)	4 (1, 9)	4 (1, 8)	4 (2, 12)	4 (1, 11)	3 (1, 9)	4 (1, 11)	4 (2, 9)	4 (1, 10)	4 (1, 8)	4 (2, 8)
		post_p	0.1 (0.01, 0.36)	0.29 (0.12, 0.47)	0.19 (0.05, 0.43)	0.19 (0.06, 0.42)	0.27 (0.12, 0.47)	0.29 (0.1, 0.47)	0.33 (0.18, 0.48)	0.31 (0.15, 0.46)	0.28 (0.11, 0.44)	0.29 (0.16, 0.43)	0.29 (0.16, 0.45)	0.32 (0.15, 0.45)	0.32 (0.17, 0.46)	0.32 (0.12, 0.47)	0.29 (0.17, 0.45)	0.29 (0.15, 0.44)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.122 (0.095, 0.182)	0.142 (0.086, 0.405)	0.125 (0.087, 0.223)	0.135 (0.093, 0.359)	0.128 (0.084, 0.261)	0.141 (0.091, 0.335)	0.141 (0.09, 0.485)	0.153 (0.101, 0.487)	0.137 (0.082, 0.408)	0.165 (0.09, 0.511)	0.147 (0.09, 0.456)	0.123 (0.088, 0.394)	0.143 (0.084, 0.453)	0.144 (0.086, 0.357)	0.156 (0.08, 0.479)	0.157 (0.09, 0.416)
	Hormone_therapies	count	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100	100
		time	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)	26 (4, 35)
		n	20 (13, 44)	4 (1, 8)	10 (5, 32)	6 (2, 26)	2 (0, 7)	2 (0, 9)	2 (0, 8)	2 (0, 7)	4 (0, 12)	3 (1, 10)	3 (0, 10)	3 (0, 9)	2 (0, 7)	2 (0, 7)	2 (0, 7)	2 (0, 7)
		post_p	0.13 (0.01, 0.41)	0.3 (0.13, 0.45)	0.19 (0.04, 0.43)	0.28 (0.05, 0.46)	0.31 (0.11, 0.42)	0.35 (0.12, 0.46)	0.33 (0.16, 0.47)	0.34 (0.19, 0.48)	0.3 (0.12, 0.45)	0.3 (0.18, 0.48)	0.3 (0.13, 0.47)	0.28 (0.16, 0.46)	0.34 (0.18, 0.45)	0.32 (0.16, 0.49)	0.33 (0.19, 0.44)	0.35 (0.21, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.115 (0.088, 0.16)	0.161 (0.079, 0.455)	0.129 (0.082, 0.248)	0.127 (0.081, 0.396)	0.154 (0.083, 0.556)	0.16 (0.07, 0.384)	0.132 (0.072, 0.436)	0.165 (0.08, 0.537)	0.133 (0.068, 0.411)	0.156 (0.063, 0.607)	0.152 (0.086, 0.548)	0.155 (0.087, 0.451)	0.153 (0.076, 0.606)	0.149 (0.085, 0.693)	0.158 (0.081, 0.522)	0.146 (0.092, 0.516)
	Niraparib	count	79	79	79	79	79	79	79	79	79	79	79	79	79	79	79	79
		time	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)	29 (21, 35)
		n	19 (8, 58)	4 (1, 10)	11 (4, 37)	8 (3, 18)	6 (2, 12)	5 (3, 13)	4 (1, 9)	3 (1, 7)	5 (2, 10)	3 (1, 11)	4 (1, 10)	3 (2, 10)	4 (1, 8)	4 (1, 8)	4 (1, 7)	3 (2, 8)
		post_p	0.16 (0.02, 0.39)	0.31 (0.12, 0.43)	0.14 (0.03, 0.4)	0.25 (0.08, 0.46)	0.29 (0.12, 0.46)	0.25 (0.08, 0.47)	0.34 (0.17, 0.48)	0.3 (0.16, 0.44)	0.29 (0.11, 0.46)	0.3 (0.12, 0.44)	0.29 (0.13, 0.46)	0.3 (0.17, 0.48)	0.3 (0.17, 0.46)	0.34 (0.16, 0.47)	0.3 (0.13, 0.46)	0.28 (0.14, 0.43)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.116 (0.089, 0.165)	0.147 (0.096, 0.492)	0.126 (0.091, 0.28)	0.123 (0.086, 0.286)	0.125 (0.091, 0.307)	0.136 (0.087, 0.349)	0.136 (0.076, 0.408)	0.176 (0.093, 0.465)	0.141 (0.084, 0.325)	0.17 (0.081, 0.559)	0.177 (0.088, 0.533)	0.141 (0.089, 0.387)	0.145 (0.086, 0.485)	0.141 (0.088, 0.555)	0.151 (0.089, 0.41)	0.182 (0.096, 0.773)
DRD+	Carboplatin	count					183	183	183	183					183	183	183	183
		time					26 (17, 34)	26 (17, 34)	26 (17, 34)	26 (17, 34)					26 (17, 34)	26 (17, 34)	26 (17, 34)	26 (17, 34)
		n					7 (3, 17)	7 (2, 17)	4 (2, 10)	4 (1, 9)					3 (1, 9)	5 (1, 10)	4 (1, 9)	4 (1, 9)
		post_p					0.28 (0.09, 0.47)	0.3 (0.11, 0.47)	0.34 (0.16, 0.48)	0.35 (0.16, 0.48)					0.32 (0.14, 0.48)	0.33 (0.14, 0.47)	0.31 (0.17, 0.45)	0.33 (0.15, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.136 (0.088, 0.308)	0.129 (0.088, 0.288)	0.127 (0.078, 0.334)	0.152 (0.088, 0.477)					0.16 (0.083, 0.548)	0.131 (0.085, 0.347)	0.162 (0.081, 0.487)	0.149 (0.082, 0.47)
	Hormone_therapies	count					111	111	111	111					111	111	111	111
		time					30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)					30 (23, 35)	30 (23, 35)	30 (23, 35)	30 (23, 35)
		n					4 (1, 14)	4 (1, 11)	5 (1, 9)	4 (1, 9)					4 (1, 10)	4 (1, 9)	4 (1, 9)	4 (1, 8)
		post_p					0.27 (0.11, 0.41)	0.28 (0.09, 0.45)	0.33 (0.16, 0.47)	0.34 (0.19, 0.46)					0.34 (0.17, 0.47)	0.34 (0.17, 0.47)	0.34 (0.17, 0.47)	0.32 (0.21, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.148 (0.1, 0.596)	0.154 (0.084, 0.423)	0.136 (0.086, 0.497)	0.155 (0.084, 0.701)					0.14 (0.079, 0.564)	0.148 (0.081, 0.44)	0.149 (0.082, 0.517)	0.149 (0.09, 0.404)
	Niraparib	count					175	175	175	175					175	175	175	175
		time					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)
		n					7 (3, 13)	6 (2, 13)	4 (1, 9)	4 (1, 8)					4 (1, 9)	4 (1, 9)	4 (2, 9)	3 (1, 8)
		post_p					0.3 (0.11, 0.46)	0.3 (0.1, 0.47)	0.34 (0.18, 0.47)	0.34 (0.17, 0.47)					0.32 (0.17, 0.48)	0.34 (0.16, 0.48)	0.33 (0.17, 0.47)	0.3 (0.16, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.129 (0.087, 0.25)	0.139 (0.088, 0.37)	0.144 (0.082, 0.457)	0.151 (0.082, 0.521)					0.146 (0.087, 0.564)	0.147 (0.082, 0.517)	0.15 (0.079, 0.365)	0.17 (0.091, 0.483)
TEfus+	Carboplatin	count		191		191		191		191		191		191		191		191
		time		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)		25 (17, 34)
		n		5 (2, 13)		9 (3, 22)		7 (3, 17)		4 (2, 9)		4 (2, 10)		4 (1, 10)		4 (1, 9)		4 (1, 9)
		post_p		0.31 (0.11, 0.48)		0.23 (0.06, 0.46)		0.32 (0.1, 0.47)		0.34 (0.17, 0.47)		0.33 (0.15, 0.47)		0.32 (0.17, 0.45)		0.32 (0.14, 0.46)		0.31 (0.16, 0.44)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.136 (0.078, 0.345)		0.127 (0.087, 0.26)		0.128 (0.08, 0.331)		0.146 (0.091, 0.477)		0.138 (0.08, 0.524)		0.133 (0.083, 0.454)		0.143 (0.086, 0.4)		0.15 (0.088, 0.505)
	Hormone_therapies	count		198		198		198		198		198		198		198		198
		time		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)
		n		5 (3, 13)		11 (4, 25)		3 (1, 12)		3 (0, 8)		4 (2, 11)		4 (2, 10)		3 (1, 8)		3 (1, 8)
		post_p		0.28 (0.1, 0.46)		0.27 (0.06, 0.46)		0.34 (0.16, 0.45)		0.36 (0.19, 0.48)		0.3 (0.13, 0.46)		0.28 (0.14, 0.47)		0.36 (0.19, 0.47)		0.35 (0.2, 0.47)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.138 (0.086, 0.302)		0.117 (0.079, 0.226)		0.15 (0.089, 0.419)		0.148 (0.079, 0.562)		0.145 (0.082, 0.372)		0.132 (0.087, 0.45)		0.141 (0.082, 0.415)		0.15 (0.081, 0.43)
	Niraparib	count		209		209		209		209		209		209		209		209
		time		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)		23 (15, 35)
		n		4 (1, 11)		8 (3, 20)		6 (2, 14)		4 (1, 9)		4 (1, 10)		3 (1, 10)		4 (1, 9)		4 (2, 8)
		post_p		0.31 (0.14, 0.47)		0.26 (0.1, 0.48)		0.3 (0.1, 0.47)		0.34 (0.17, 0.47)		0.31 (0.14, 0.46)		0.32 (0.16, 0.48)		0.33 (0.15, 0.48)		0.3 (0.14, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.143 (0.086, 0.519)		0.127 (0.079, 0.271)		0.136 (0.08, 0.349)		0.15 (0.086, 0.434)		0.145 (0.076, 0.565)		0.149 (0.084, 0.38)		0.148 (0.082, 0.455)		0.163 (0.091, 0.473)
TP53- & AR-	Carboplatin	count	390	390			390	390
		time	21 (14, 31)	21 (14, 31)			21 (14, 31)	21 (14, 31)
		n	20 (8, 60)	5 (2, 12)			7 (3, 16)	7 (3, 17)
		post_p	0.19 (0.03, 0.45)	0.35 (0.15, 0.48)			0.32 (0.14, 0.47)	0.34 (0.12, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.112 (0.084, 0.182)	0.131 (0.077, 0.333)			0.128 (0.085, 0.289)	0.127 (0.085, 0.334)
	Hormone_therapies	count	409	409			409	409
		time	17 (9, 30)	17 (9, 30)			17 (9, 30)	17 (9, 30)
		n	23 (16, 56)	6 (3, 14)			4 (1, 12)	4 (1, 12)
		post_p	0.17 (0.02, 0.39)	0.33 (0.12, 0.47)			0.36 (0.18, 0.48)	0.37 (0.19, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.116 (0.089, 0.159)	0.13 (0.081, 0.289)			0.134 (0.071, 0.554)	0.134 (0.074, 0.428)
	Niraparib	count	403	403			403	403
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	19 (8, 58)	5 (2, 14)			7 (3, 15)	6 (2, 15)
		post_p	0.19 (0.03, 0.44)	0.36 (0.17, 0.47)			0.35 (0.15, 0.48)	0.32 (0.11, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.086, 0.171)	0.131 (0.079, 0.412)			0.119 (0.078, 0.283)	0.133 (0.085, 0.358)
TP53+	Carboplatin	count			223	223			223	223			223	223			223	223
		time			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)			24 (14, 34)	24 (14, 34)
		n			11 (5, 36)	9 (3, 25)			4 (2, 10)	4 (2, 9)			4 (1, 10)	4 (1, 11)			4 (1, 8)	4 (1, 8)
		post_p			0.21 (0.04, 0.46)	0.27 (0.11, 0.46)			0.34 (0.17, 0.48)	0.35 (0.18, 0.48)			0.31 (0.13, 0.46)	0.35 (0.18, 0.47)			0.32 (0.18, 0.47)	0.32 (0.17, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.122 (0.086, 0.248)	0.119 (0.087, 0.243)			0.138 (0.076, 0.403)	0.149 (0.086, 0.477)			0.149 (0.083, 0.53)	0.13 (0.08, 0.494)			0.158 (0.083, 0.535)	0.15 (0.088, 0.506)
	Hormone_therapies	count			229	229			229	229			229	229			229	229
		time			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)			24 (13, 34)	24 (13, 34)
		n			14 (7, 44)	9 (4, 28)			3 (1, 9)	3 (0, 8)			4 (2, 12)	4 (2, 11)			3 (1, 8)	3 (1, 9)
		post_p			0.18 (0.03, 0.43)	0.24 (0.07, 0.45)			0.35 (0.18, 0.48)	0.35 (0.17, 0.48)			0.33 (0.14, 0.47)	0.31 (0.15, 0.47)			0.34 (0.19, 0.47)	0.36 (0.17, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.117 (0.088, 0.197)	0.122 (0.084, 0.251)			0.137 (0.074, 0.617)	0.154 (0.083, 0.607)			0.144 (0.084, 0.418)	0.13 (0.076, 0.48)			0.16 (0.078, 0.54)	0.145 (0.084, 0.44)
	Niraparib	count			231	231			231	231			231	231			231	231
		time			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)			24 (15, 33)	24 (15, 33)
		n			12 (4, 37)	8 (3, 19)			4 (1, 9)	4 (1, 8)			4 (1, 10)	3 (1, 10)			4 (2, 8)	3 (1, 9)
		post_p			0.19 (0.06, 0.44)	0.25 (0.08, 0.46)			0.35 (0.17, 0.48)	0.33 (0.17, 0.47)			0.34 (0.14, 0.48)	0.33 (0.16, 0.47)			0.34 (0.15, 0.48)	0.31 (0.14, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.121 (0.09, 0.25)	0.131 (0.086, 0.281)			0.136 (0.077, 0.384)	0.157 (0.082, 0.43)			0.145 (0.084, 0.437)	0.14 (0.081, 0.385)			0.145 (0.078, 0.334)	0.174 (0.093, 0.455)